Trial reportInternational ophthalmology2025
The effects of povidone-ıodine and chlorhexidine gluconate on the ocular surface after phacoemulsification cataract surgery.
Trial report in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
purposeTo compare the effects of 5% povidone-iodine (PI) and 0.1% chlorhexidine gluconate (CHG) on ocular surface parameters and patient comfort following phacoemulsification cataract surgery. The study aimed to determine whether CHG offers advantages over PI in terms of ocular surface recovery and postoperative comfort.
methodsThis prospective, randomized controlled trial included 61 patients undergoing phacoemulsification for senile cataract. Participants were randomly assigned to conjunctival irrigation with either 5% PI or 0.1% CHG for 3 min before surgery. Ocular surface assessments included Schirmer test, tear break-up time (TBUT), tear meniscus height (TMH), and the Ocular Surface Disease Index (OSDI). Evaluations were performed preoperatively and postoperatively at Week 1, Month 1, and Month 3. Pain scores were recorded using a numerical rating scale within the first 24 h.
resultsBaseline parameters were comparable between groups. At Week 1, OSDI scores were significantly higher in the PI group than in the CHG group (p = 0.029). Both groups showed significant early postoperative deterioration of ocular surface parameters, but recovery was faster in the CHG group. TBUT remained significantly reduced in the PI group at Month 3, whereas CHG eyes normalized. Schirmer values returned to baseline by Month 1 in both groups. Postoperative pain scores were significantly higher in the PI group (p < 0.001).
conclusionBoth PI and CHG caused transient ocular surface changes after cataract surgery. However, CHG demonstrated faster recovery of tear film parameters and improved early postoperative comfort, suggesting it may be a preferable antiseptic in patients with ocular surface sensitivity.
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