ArticleWorld journal of urology2025
Beyond venous dilatation: Nutcracker syndrome and Its Unique Hemodynamic Signature in Adolescent Varicocele.
Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study evaluates the association between Nutcracker Syndrome (NCS) and adolescent varicocele, focusing on hemodynamic parameters, symptom patterns, and diagnostic thresholds to optimize clinical management.
methodsIn this prospective study, 56 adolescents (mean age 14.9 ± 2.1 years) with Grade II-III varicocele underwent standardized Doppler ultrasonography to assess pampiniform plexus diameters, SMA-Aorta angles, and renal vein dynamics. NCS was defined as a standing SMA-Aorta angle < 30°. Groups were stratified by NCS status and pampiniform plexus diameter (≥ 2.8 mm vs. <2.8 mm). Symptom profiles (pain, palpable mass) and hemodynamic differences were analyzed (Tables 2 and 3).
resultsNCS prevalence was 71.4%. NCS(+) patients had lower BMI (p = 0.018), growth percentiles (p = 0.003), and narrower SMA-Aorta angles (standing: 16.9° vs. 26.6°, p < 0.001). Pampiniform plexus diameters were larger in NCS(+) cases (resting: 3.0 vs. 2.2 mm, p < 0.001). When the groups were evaluated in terms of isolated pain, no difference was found between them (p = 1.000), while NCS(-) patients had higher pain-mass combination scores (p = 0.012). When cases with pampiniform plexus diameter ≥ 2.8 mm were compared, significant associations were demonstrated: larger Valsalva diameters (4.50 vs. 3.01 mm, p < 0.001), narrower SMA-Aorta angles (standing: 17.3° vs. 21.4°, p = 0.008), and lower BMI percentile values (p = 0.008) were observed.
conclusionNCS is prevalent in adolescent varicocele and linked to distinct hemodynamic and anthropometric profiles. Key findings include: Symptom paradox: NCS(−) patients reported more pain-mass combinations (p = 0.012). Diagnostic thresholds: Pampiniform diameter ≥ 2.8 mm and standing SMA-Aorta angle < 25° are critical markers. Routine postural Doppler screening is recommended for adolescents with varicocele, especially those with low BMI.
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