ArticlePediatric nephrology (Berlin, Germany)2026
Which glomerular filtration rate estimation equations should be used in youth with type 1 diabetes?
Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Late-adolescent weight categories and early kidney disease in young adulthood: a nationwide study of Arab and Jewish Israelis.Pediatric nephrology (Berlin, Germany) · 2026Article
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3 authors.
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Abstract
backgroundDiabetic kidney disease (DKD) is the primary cause of kidney failure in type 1 diabetes (T1D). Early identification of subclinical DKD is based on albuminuria and glomerular filtration rate (GFR). However, no GFR equations have been validated in youth with T1D. This study evaluates the performance of GFR equations in youth with T1D.
methodsWe compared a direct measure of GFR (mGFR) via plasma clearance of exogenous inulin, with estimated GFR (eGFR). eGFR was calculated with the following equations: Full-Age Spectrum (FAS-height and FAS-age); revised Lund-Malmö (LM-Rev); European Kidney Function Consortium (EKFC); Chronic Kidney Disease Epidemiology Collaboration, 2009 (CKD-EPI 2009); CKD-EPI 2021 (revised CKD-EPI 2009 without race adjustment); CKD-EPI40 (revised CKD-EPI 2021 with age-adjusted creatinine); Chronic Kidney Disease in Children (CKiD); CKiD Under 25 (sex-dependent); CKiD Under 25 (age- and sex-dependent); and Improving Renal Complications in Adolescents with Type 2 Diabetes through Research (iCARE). Bland-Altman analysis estimated performance (bias and accuracy (P10 and P30)).
resultsIn total, 141 children and adolescents at a mean age of 13.5 ± 3.3 years (range 6.2-18.5) and diabetes duration 5.7 ± 1.6 years were included. Their mean serum creatinine was 45.6 ± 12.1 μmol/L (0.52 ± 0.14 mg/dL) and mGFR 142.3 ± 25.0 mL/min/1.73 m
conclusionsSubgroups of children and adolescents with T1D may benefit from different eGFR equations for accurate subclinical DKD evaluation.
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