Evidence map›Paper›PMID 41239844›Full record

ReviewJournal of cutaneous pathology2026

TRPS1::PLAG1 Fusion in a Primary Cutaneous Myoepithelial Carcinoma: A Case Report and Literature Review.

Timber Gillis, Jenika Howell, Fatemeh Jafarian

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cutaneous pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Timber GillisUniversity of Calgary, Calgary, Canada.ORCID https://orcid.org/0000-0001-7099-4539
Jenika HowellUniversity of Calgary, Calgary, Canada.
Fatemeh JafarianUniversity of Calgary, Calgary, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myoepithelial neoplasms are rare tumors that are found in the salivary glands, the breast, soft tissue, and skin. Myoepithelial carcinomas typically have a poor prognosis with a high rate of local recurrence and metastasis in the cutaneous setting. There are fewer than 30 described cases of primary cutaneous myoepithelial carcinoma in the literature. We performed a literature review and identified 26 known cases of primary cutaneous myoepithelial carcinoma. Here, we describe a case of occipital primary cutaneous myoepithelial carcinoma occurring in a 56-year-old patient. RNA sequencing was performed on the tumor which identified a TRPS1::PLAG1 fusion event which is to our knowledge, the first time this has been reported in the literature for a primary cutaneous myoepithelial carcinoma.

Indexed as

DNA-Binding ProteinsMyoepitheliomaOncogene Proteins, FusionSkin NeoplasmsTranscription FactorsHumansRepressor ProteinsTranscriptional Coactivator with PDZ-Binding Motif ProteinsDNA-Binding ProteinsOncogene Proteins, FusionPLAG1 protein, humanRepressor ProteinsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsTRPS1 protein, humanmyoepithelial carcinomaPLAG1RNAsequence analysisskin neoplasmsTRPS1

Identifiers

PMID41239844
PMCPMC12779169

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.