ArticleJournal of neuroendocrinology2026
Unraveling the impact of oxytocin receptor gene methylation on stress and inflammation in older adults.
Kylie A Wright, Rebecca J Polk, Tian Lin, Shanting Chen, Janie Yang, Kathleen Krol, Allison Perkeybile, Armando Mendez, Jessica Connelly, Natalie C Ebner
Abstract read
In one paragraphArticle in Journal of neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Rebecca J PolkDepartment of Psychology, Washington University, St. Louis, Missouri, USA.
Tian LinDepartment of Psychology, University of Florida, Gainesville, Florida, USA.
Shanting ChenDepartment of Psychology, University of Florida, Gainesville, Florida, USA.
Janie YangDepartment of Psychology, University of Florida, Gainesville, Florida, USA.
Kathleen KrolDepartment of Psychology, University of Virginia, Charlottesville, Virginia, USA.
Allison PerkeybileDepartment of Psychology, University of Virginia, Charlottesville, Virginia, USA.
Armando MendezDivision of Endocrinology, Diabetes, and Metabolism, University of Miami Miller School of Medicine, Miami, Florida, USA.
Jessica ConnellyDepartment of Psychology, University of Virginia, Charlottesville, Virginia, USA.
Natalie C EbnerDepartment of Psychology, University of Florida, Gainesville, Florida, USA.
Funding
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8MCharacterizing and Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging (Diversity Supplement)R01AG072658 · NIA · UNIVERSITY OF FLORIDA · PI Natalie C Ebner, Nichole Lighthall · 2022 to 2026
$3.6MMechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)R01AG059809 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, EBNER, NATALIE C · 2018 to 2022
$1.8MThe potential of oxytocin to reduce opioid abuse liability and pain among older adultsR21DA056813 · NIDA · UNIVERSITY OF FLORIDA · PI BERRY, MEREDITH, CRUZ-ALMEIDA, YENISEL · 2023 to 2024
$419kClaude D. Pepper Older Americans Independence Center, University of Florida P30AG028740College of Liberal Arts and Sciences, University of FloridaInstitute on Aging, College of Medicine, University of Florida ARG DTD 03-26-2008NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG059809NIA NIH HHS R01AG059809NIA NIH HHS R01 AG072658NIA NIH HHS R01AG072658-02S2NIDA NIH HHS R21 DA056813NIDA NIH HHS R21DA056813Office of Naval Research N00014-21-1-2201UF Center for Cognitive Aging and MemoryUF Jacquelin Goldman Research GrantUF McKnight Brain InstituteUF Trish Calvert Ring Research Award and Endowed ProfessorshipUniversity of Florida Department of PsychologyUniversity of Florida Jacquelin Goldman Research GrantUniversity of Florida Trish Calvert Ring Research Award
6 · The paper itselfAbstract
Oxytocin (OT) is a neuropeptide involved, among other functions, in the regulation of stress and inflammation. OT's impact on inflammatory and stress-related processes is particularly relevant in older adults, given that elevated levels of systemic inflammation typically associated with age can be amplified by stress. Methylation of the OT receptor gene (OXTRm) is an epigenetic process that reduces the availability of receptors to bind with OT. While acute stress has been shown to increase OXTRm levels in older adults, the interplay of OXTRm and stress on inflammation remains unexamined. This study collected blood samples from 116 generally healthy older adults (M
Indexed as
AgingDNA MethylationInflammationReceptors, OxytocinStress, PsychologicalAgedAged, 80 and overEpigenesis, GeneticFemaleHumansMaleMiddle AgedTumor Necrosis Factor-alphaOXTR protein, humanReceptors, OxytocinTumor Necrosis Factor-alphaagingoxytocin receptor gene methylationstresssystemic inflammation
Identifiers
PMID41239825
PMCPMC12721307
What OpenQuestion holds
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