ArticleThe Journal of international medical research2025
Factors associated with umbilical arterial blood pH in term neonates delivered via cesarean section: A retrospective cohort study.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The Impact of First-Trimester Vaginal Microecology on Spontaneous Abortion: A Retrospective Cohort Study.Pathogens (Basel, Switzerland) · 2026Article
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6 authors.
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Abstract
ObjectiveThis retrospective cohort study aimed to identify perinatal factors associated with umbilical arterial pH in term neonates delivered via cesarean section, using a pH cutoff of 7.20 to define neonatal acidosis.MethodsWe analyzed clinical data from 356 mother-neonate dyads who underwent cesarean delivery at a tertiary hospital between January 2020 and December 2022. Neonates were categorized into two groups based on umbilical arterial pH values (<7.20 vs. ≥7.20). We evaluated maternal and intrapartum factors, including amniotic fluid quality (operationally defined as clear or meconium-stained (grades I-III)), duration of labor, and fetal distress. Statistical analyses included multivariable logistic regression to quantify associations (reported as odds ratios with 95% confidence intervals) and random forest modeling to identify key predictors. Model performance was assessed via receiver operating characteristic curve analysis.ResultsThe incidence of acidosis (umbilical arterial pH <7.20) was 51.0% (52/102). Meconium-stained amniotic fluid (adjusted odds ratio: 3.12; 95% confidence interval: 1.75-5.58; p < 0.001) and trial of labor (adjusted odds ratio: 2.45; 95% confidence interval: 1.40-4.30; p = 0.002) were significantly associated with acidosis. The random forest model identified these factors as the top predictors, with an area under the curve of 0.71 (95% confidence interval: 0.68-0.74) based on 10-fold cross-validation.ConclusionMeconium-stained amniotic fluid and prolonged labor are strongly associated with acidosis in term cesarean deliveries. Early identification of these factors may aid in risk stratification and perinatal management.
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