ArticleActa neuropathologica communications2025
Molecular insights into prognostic model for meningiomas treated with stereotactic radiosurgery: negative impacts of 1q gain on tumor control and survival.
Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Modeling meningioma in vitro in the omics era.Human cell · 2026Review
- Correction: Molecular insights into prognostic model for meningiomas treated with stereotactic radiosurgery: negative impacts of 1q gain on tumor control and survival.Acta neuropathologica communications · 2025Article
Corrections and comments
- Erratum issued
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16 authors.
Funding
Abstract
Molecular classifications enhance prognostic accuracy in meningiomas; however, their predictive significance following stereotactic radiosurgery (SRS) remains unclear. This study aimed to assess whether molecular characteristics identified by whole-exome sequencing (WES), specifically driver mutations and copy number alterations (CNAs), are prognostic indicators of outcomes after SRS. This retrospective cohort study included 95 patients (median age 61; 66% female) with 97 surgically resected meningiomas treated with SRS between 1999 and 2023. Primary outcomes were progression-free survival (PFS) and disease-specific survival (DSS). Tumors were molecularly classified using WES into Group A (NF2-wildtype), Group B (NF2 mutation/22q loss without high-risk CNAs), and Group C (high-risk CNAs including 1p loss, 1q gain, 6p/6q loss, 10p/10q loss, 14q loss, 18p/18q loss, and CDKN2A/B homozygous deletion). Group C exhibited significantly inferior PFS at 5 years (49.7%) compared with Groups A (88.5%, p < 0.001) and B (100%, p = 0.002). DSS at 10 years was also significantly reduced in Group C (60.4%) relative to Groups A and B (100%, p < 0.001 and p = 0.016, respectively). Within Group C, 1q gain correlated strongly with poorer outcomes, with significantly lower 5-year PFS (15.9% vs. 64.3%, p < 0.001) and DSS (51.3% vs. 90.4%, p < 0.001). Furthermore, even WHO grade 1 tumors with 1q gain demonstrated significantly worse outcomes (5-year PFS: 33.3% vs. 76.5%, p = 0.023; DSS: 44.4% vs. 89.3%, p = 0.011). Molecular classification utilizing WES-derived CNAs substantially improves prognostic prediction after SRS for meningiomas. Chromosome 1q gain was a critical biomarker indicating elevated risk for tumor progression and mortality, even among WHO grade 1 tumors.
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