Evidence map›Paper›PMID 41239456›Full record

ArticleEuropean journal of medical research2025

Pan-cancer analysis identifies LMBR1L as a prognostic and immunological biomarker with validation in colorectal cancer.

Song Liang, Weiwei Yuan, Yin Shi, Yongkang Liang, Hengbo Xia, Chen Chen, Chuansi Wang, Pin Jiang, Juhe Zhang, Shenwei Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Song Liang *Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Avenue, Road, Hefei, 230022, Anhui, China.
Weiwei Yuan *Department of Thyroid Surgery, Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201999, China.
Yin Shi *Department of Internal Medicine, Yiwu Maternity and Children Hospital, Yiwu, 32200, Zhejiang, China.
Yongkang LiangDepartment of General Surgery, Lu'an Affiliated Hospital of Anhui Medical University, No. 21 West Wanxi Road, Lu'an, 237000, Anhui, China.
Hengbo XiaDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Avenue, Road, Hefei, 230022, Anhui, China.
Chen ChenDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Avenue, Road, Hefei, 230022, Anhui, China.
Chuansi WangDepartment of General Surgery, Lu'an Affiliated Hospital of Anhui Medical University, No. 21 West Wanxi Road, Lu'an, 237000, Anhui, China.
Pin JiangDepartment of General Surgery, Lu'an Affiliated Hospital of Anhui Medical University, No. 21 West Wanxi Road, Lu'an, 237000, Anhui, China.
Juhe ZhangDepartment of General Surgery, Lu'an Affiliated Hospital of Anhui Medical University, No. 21 West Wanxi Road, Lu'an, 237000, Anhui, China.
Shenwei WuDepartment of General Surgery, Lu'an Affiliated Hospital of Anhui Medical University, No. 21 West Wanxi Road, Lu'an, 237000, Anhui, China.
Aman XuDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Avenue, Road, Hefei, 230022, Anhui, China. xuaman@ahmu.edu.cn.

Funding

the Anhui Province Traditional Chinese Medicine Inheritance and Innovation Research Program No. 2024CCCX062the Lu'an Science and Technology Program of Anhui Province No. 2024lakj001the Scientific Research Project of Bengbu Medical College No. 2024byzd274
6 · The paper itself

Abstract

The limb development membrane protein 1-like gene (LMBR1L) encodes a transmembrane protein involved in cellular signaling and molecular transport. LMBR1L plays a critical role in immune system development by negatively regulating the Wnt/β-catenin pathway in lymphocytes. However, its role in the tumor immune microenvironment and its potential as a predictor of immunotherapy response remain poorly understood. We analyzed LMBR1L expression in normal and tumor tissues using data from public databases and clinical samples. Prognostic significance and immune associations were assessed using survival analysis, Gene Set Enrichment Analysis (GSEA), Gene Set Variation Analysis (GSVA), and immune infiltration profiling tools. Additionally, both in vitro and in vivo experiments were conducted to assess the effects of LMBR1L knockdown in colorectal cancer (COAD) cells. Elevated LMBR1L expression was observed in multiple cancers. Single-cell sequencing revealed its primary expression in CD8

Indexed as

Biomarkers, TumorColorectal NeoplasmsMembrane ProteinsAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMicePrognosisTumor MicroenvironmentBiomarkers, TumorMembrane ProteinsImmune cell infiltrationLMBR1L expressionPan-cancer analysisPrognostic biomarkerTumor immune microenvironment

Identifiers

PMID41239456
PMCPMC12616993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.