Evidence map›Paper›PMID 41239453›Full record

SynthesisMalaria journal2025

Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis.

Peta Edler, Megha Rajasekhar, David J Price, Ishag Adam, Ghulam Rahim Awab, Bridget E Barber, Larissa W Brasil, Nathália N Chamma-Siqueira, Cindy S Chu, Liwang Cui and 37 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Peta EdlerDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Megha RajasekharCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
David J PriceDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Ishag AdamDepartment of Obstetrics and Gynecology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Ghulam Rahim AwabMahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Bridget E BarberQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Larissa W BrasilDiretoria de Ensino e Pesquisa, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
Nathália N Chamma-SiqueiraLaboratório de Malária, Instituto Evandro Chagas, Ministério da Saúde do Brasil, Ananindeua, Pará State, Brazil.
Cindy S ChuShoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Liwang CuiDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
André DaherFiocruz Clinical Research Platform, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Margarete do Socorro M GomesSuperintendência de Vigilância em Saúde do Estado do Amapá - SVS/AP, Macapá, Amapá, Brazil.
Lilia Gonzalez-CeronRegional Centre for Public Health Research, National Institute for Public Health, Tapachula, Chiapas, Mexico.
Matthew J GriggGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
Harin KarunajeewaDepartment of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St. Albans, VIC, Australia.
Marcus V G LacerdaFundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.
Simone Ladeia-AndradeLaboratory of Parasitic Diseases, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
Toby LeslieDepartment of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Benedikt LeyGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
Kartini LidiaThe Department of Pharmacology and Therapy, Faculty of Medicine and Veterinary Medicine, Universitas Nusa Cendana, Kupang, Indonesia.
Alejandro Llanos-CuentasUnit of Leishmaniasis and Malaria, Instituto de Medicina Tropical "Alexander Von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.
Rhea J LongleyMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Laurens ManningMedical School, University of Western Australia, Crawley, Australia.
Daniel Abebe MekonnenMalaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
Wuelton Marcelo MonteiroFundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.
Brioni R MooreWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Australia.
Francois NostenShoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Ayodhia Pitaloka PasaribuDepartment of Pediatrics, Medical Faculty, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia.
Dhelio B PereiraCentro de Pesquisa Em Medicina Tropical de Rondonia (CEPEM), Porto Velho, Brazil.
Jeanne Rini PoespoprodjoMimika District Hospital, Timika, Indonesia.
Sasithon PukrittayakameeMahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Komal Raj RijalCentral Department of Microbiology, Tribhuvan University, Kirtipur, Nepal.
Kavitha SaravuDepartment of Infectious Diseases, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Madhava Nagar, Manipal, Karnataka, India.
André M SiqueiraInstituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Inge SutantoDepartment of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
Walter R J TaylorMahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pham Vinh ThanhParasitology and Entomology, National Institute of Malariology, Hanoi, Vietnam.
Kamala ThriemerGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
José Luiz F VieiraFederal University of Pará (Universidade Federal Do Pará - UFPA), Belém, Pará, Brazil.
Nicholas J WhiteMahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Asnakew K YeshiwondimWorld Health Organization Country Office for Addis Ababa, Addis Ababa, Ethiopia.
Lina M Zuluaga-IdarragaGrupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Philippe J GuerinCentre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Julie A SimpsonCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Ric N PriceGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
Robert J CommonsGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia. rob.commons@wwarn.org.
WorldWide Antimalarial Resistance Network (WWARN) Vivax Primaquine Dosing Efficacy, Tolerability and Safety Study Group

Funding

National Health and Medical Research Council 1173210National Health and Medical Research Council 1194702National Health and Medical Research Council 1196068National Health and Medical Research Council 1197177National Health and Medical Research Council 2008501National Health and Medical Research Council 2016792National Health and Medical Research Council 2017436National Health and Medical Research Council 2033264Wellcome TrustWellcome Trust 093956World Health Organization 001
6 · The paper itself

Abstract

backgroundThe antirelapse efficacy of primaquine is related to the total dose administered, whereas the risks of haemolysis and gastrointestinal intolerance are associated with the daily dose administered. National Malaria Control Programmes require local information on efficacy, tolerability and safety to optimize antimalarial treatment policies for Plasmodium vivax malaria control and elimination efforts.

methodsA living systematic review identified efficacy studies of uncomplicated P. vivax malaria including patients treated with daily primaquine regimens, published since January 1, 2000. Available data were pooled and an R Shiny app was developed to integrate statistical analyses performed using R and Stata that assessed the impact of primaquine mg/kg dose on efficacy, hematological safety and gastrointestinal tolerability.

resultsAs of January 16, 2025, a total of 9,270 individual patient data records from 41 studies have been collated into the standardized repository. Open-access automated reports were generated for user-selected countries or regions to investigate location specific effects of primaquine dose on efficacy, safety and tolerability. The reports include visual and tabular displays of the outcomes.

conclusionsThese automated reports leverage a large database to provide accessible data for national and regional policy makers and researchers to assess the clinical consequences of different primaquine regimens in different endemic settings. The reports will inform local and regional policy decisions and research priorities in vivax-endemic areas.

Indexed as

AntimalarialsMalaria, VivaxPrimaquineHumansPlasmodium vivaxTreatment OutcomeAntimalarialsPrimaquineAutomated reportDoseEfficacyHaemolysisMalariaPlasmodium vivaxPrimaquineRecurrenceRelapseTolerability

Identifiers

PMID41239453
PMCPMC12619205

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.