Evidence map›Paper›PMID 41239380›Full record

ArticleBMC public health2025

Real-world analysis and future trends of parkinson's disease burden and all-cause mortality in Shanghai Pudong: a population-based study of 3.17 million people.

Zheng Luo, Jie Xue, Yan Zhang, Yichen Chen, Aiqing Fan, Ru Liu, Wenchang Jia, Xiaoling Wu, Qizhe Wang, Huihui Lv and 2 more

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Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Zheng Luo *Department of Neurology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Rd.,Pudong, Shanghai, 201318, China.
Jie Xue *Department of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China.
Yan Zhang *Department of Neurology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Rd.,Pudong, Shanghai, 201318, China.
Yichen Chen *Office of Scientific Research and Information Management, Centre for Disease Control and Prevention, Pudong New Area, Shanghai, 200136, China.
Aiqing FanSunqiao Community Health Service Center, Pudong New Area, Shanghai, 201210, China.
Ru LiuDepartment of Health Management Centre, Zhongshan Hospital, Shanghai Medical College of Fudan University, 180 Fenglin Rd. Xuhui, Shanghai, 200032, China.
Wenchang JiaSchool of Public Health, Fudan University, Shanghai, 200032, China.
Xiaoling WuDepartment of Health Management Centre, Zhongshan Hospital, Shanghai Medical College of Fudan University, 180 Fenglin Rd. Xuhui, Shanghai, 200032, China.
Qizhe WangDepartment of Health Management Centre, Zhongshan Hospital, Shanghai Medical College of Fudan University, 180 Fenglin Rd. Xuhui, Shanghai, 200032, China.
Huihui LvDepartment of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Rd., Shanghai, 200437, China. lvhuihui@shutcm.edu.cn.
Yong BiDepartment of Neurology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Rd.,Pudong, Shanghai, 201318, China. drbiyong@126.com.
Xiaopan LiDepartment of Health Management Centre, Zhongshan Hospital, Shanghai Medical College of Fudan University, 180 Fenglin Rd. Xuhui, Shanghai, 200032, China. xiaopanli0224@126.com.

Funding

Shanghai Municipal Commission of Health and Family Planning 202340293Shanghai Pudong New Area Leading Health System Personnel Training Program PWR12023-06Special Disease Construction Project of Pudong Health and Family Planning Commission of Shanghai PWZzb2022-20the Key Discipline Construction Project of Pudong Health and Family Planning Commission of Shanghai PWYts2021-02
6 · The paper itself

Abstract

backgroundTo assess all-cause Parkinson's disease (PD)-related and PD-specific mortality trends and years of life lost (YLL) in Shanghai Pudong (3.17 million population) from 2005-2021, and project future burdens through 2035.

methodsUsing population-level mortality data including 4,218 PD-related deaths among 362,558 total deaths, we calculated crude mortality rates (CMR), age-standardized mortality rates (ASMRW), and YLL. Temporal trends were analyzed by the average annual percent change (AAPC) via Joinpoint regression, demographic impacts via decomposition methods, and future projections via ARIMA models.

resultsPD-related CMR and ASMRW were 8.74/100,000 and 2.76/100,000, respectively, with 31,904.41 YLL. PD-specific mortality rates (CMR: 3.76/100,000; ASMRW: 1.25/100,000) accounted for 14,532.50 YLL. Individuals aged ≥ 80 years exhibited highest mortality burden (CMR: 112.29/100,000). Cerebrovascular disease (18.94%) and coronary heart disease (13.54%) were leading comorbidities. Temporal analyses revealed significant annual increases in ASMRW (AAPC = 8.38%, P < 0.001) and YLL rates (AAPC = 7.03%, P < 0.001), driven predominantly by population aging (AAPC = 30.73%, P < 0.001). Projections indicate continued rises in ASMRW (AAPC = 1.49%) and YLL rates (AAPC = 3.49%) through 2035 (P < 0.001).

conclusionsPD imposes increasing mortality burden in Shanghai Pudong, with population aging as the primary driver. Multi-departmental interventions targeting early diagnosis, comorbidity management, and medical infrastructure are urgently needed.

trial registrationClinical trial number: not applicable.

Indexed as

Cost of IllnessParkinson DiseaseAdolescentAdultAgedAged, 80 and overCause of DeathChinaFemaleForecastingHumansLife ExpectancyMaleMiddle AgedMortalityYoung AdultAgingChinaForecastingMortalityParkinson’s diseaseShanghaiYears of life lost

Identifiers

PMID41239380
PMCPMC12619288

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.