Evidence map›Paper›PMID 41239319›Full record

ArticleBMC biology2025

Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin.

Tiago Mimoso, Aleksandr Korobeinikov, Alexander Stein, Dragomir Milovanovic, Silvio O Rizzoli, Sarah Köster, Sofiia Reshetniak

Abstract read
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In one paragraph

Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Tiago MimosoInstitute for X-Ray Physics, University of Göttingen, Göttingen, Germany.
Aleksandr KorobeinikovLaboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases, Berlin and Bonn, Germany.
Alexander SteinResearch Group Membrane Protein Biochemistry, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Dragomir MilovanovicLaboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases, Berlin and Bonn, Germany.
Silvio O RizzoliDepartment of Neuro- and Sensory Physiology and Biostructural Imaging of Neurodegeneration (BIN) Center, University Medical Center Göttingen, Göttingen, Germany.
Sarah KösterInstitute for X-Ray Physics, University of Göttingen, Göttingen, Germany.
Sofiia ReshetniakDepartment of Neuro- and Sensory Physiology and Biostructural Imaging of Neurodegeneration (BIN) Center, University Medical Center Göttingen, Göttingen, Germany. sofiia.reshetniak@med.uni-goettingen.de.

Funding

Deutsche Forschungsgemeinschaft EXC 2067Deutsche Forschungsgemeinschaft SFB1286/B02Deutsche Forschungsgemeinschaft SFB1286/B10European Research Council MemLessInterface (101078172)
6 · The paper itself

Abstract

backgroundThe presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years, evidence has accumulated that connects the synaptic vesicle cluster to the local dynamics of microtubule ends. Nonetheless, one question remains open, namely whether the vesicles influence the availability of tubulin within the synaptic compartment.

resultsAn analysis of previously published live imaging experiments indicates that tubulin is strongly enriched in the synaptic vesicle cluster. To analyze the vesicle-tubulin interaction directly, we isolated vesicles from the mouse brain and imaged them together with fluorescent tubulin in vitro. We found that soluble tubulin is collected by synaptic vesicles in physiological buffers, resulting in the formation of tubulin-rich regions (TRRs) on the respective vesicle clusters.

conclusionsWe conclude that the synaptic vesicle cluster is indeed able to recruit soluble tubulin.

Indexed as

BrainSynaptic VesiclesTubulinAnimalsMiceMicrotubulesTubulinCytoskeletonMicrotubulesSynapseSynaptic vesicle clusterSynaptic vesiclesTubulin

Identifiers

PMID41239319
PMCPMC12619239

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