ArticleBMC geriatrics2025
The relationship between oral frailty and cognitive function in elderly patients with chronic diseases: the chain-mediated effect of nutrition status and the inflammatory marker CRP.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of the prevalence and risk factors of oral frailty among older adults.BMC oral health · 2026Pooled it
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Authors and funding
7 authors.
Funding
Abstract
purposeThis study aims to investigate the mediating role of nutritional status and the inflammatory marker C-reactive protein (CRP) in the relationship between oral frailty and cognitive function in elderly patients with chronic diseases.
methodsA cross-sectional design was employed, and From June to December 2024, patients aged ≥ 60 years with chronic diseases from three tertiary hospitals in Henan Province were selected using convenience sampling. Data were collected using questionnaires, including the general information questionnaire, the Oral Frailty Screening Index-8 (OFI-8), the Mini Nutritional Assessment Short Form, the Montreal Cognitive Assessment, and laboratory tests for CRP. Descriptive demographic analysis and Pearson correlation analysis were conducted using SPSS 26.0, and the model 6 in macro program Process 4.1 was employed to test the chain mediation effect.
results(1) Regression analysis showed that oral frailty had a significant direct impact on cognitive function (β = -0.154, P < 0.01), and nutritional status (β = 0.228, P < 0.001) and CRP (β = -0.200, P < 0.001) also had significant effects on cognitive function. (2) The results of the mediating effect analysis showed that the simple mediating effects of nutritional status and CRP between oral frailty and cognitive function were -0.088 (95% CI: -0.138 to -0.048) and -0.056(95% CI: -0.097 to -0.029), respectively, and the chain mediating effect was - 0.022 (95% CI: -0.040 to -0.010).
conclusionThis study found direct and chain-mediated effects of nutritional status and CRP between oral frailty and cognitive function. It suggests that cognitive function can be improved by early identification of oral frailty, improving nutritional status and reducing chronic inflammation levels to delay or even reverse the onset and progression of cognitive dysfunction in elderly patients with chronic diseases.
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