Evidence map›Paper›PMID 41239254›Full record

Observational studyBMC infectious diseases2025

Ventilator-associated lower respiratory tract infections and bacteremia in medical and surgical critical care patients colonized by multidrug-resistant bacteria.

Ignacio Torres, Josep Ferrer, Javier Colomina, María Ángeles Clari, Beatriz Olea, Estela Giménez, Eliseo Albert, Pablo Sánchez-Jordán, Gerardo Aguilar, Nieves Carbonell and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ignacio TorresMicrobiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Josep FerrerMicrobiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Javier ColominaMicrobiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
María Ángeles ClariMicrobiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Beatriz OleaMicrobiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Estela GiménezMicrobiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Eliseo AlbertMicrobiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Pablo Sánchez-JordánMedical Intensive Care Unit, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Gerardo AguilarCritical Care Unit, Anesthesiology and Critical Care Department, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Nieves CarbonellMedical Intensive Care Unit, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
David NavarroMicrobiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain. david.navarro@uv.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the risk of bloodstream infections (BSI) and ventilator-associated lower respiratory tract (LRT) infections, including pneumonia (VAP) and tracheobronchitis (VAT), due to multidrug-resistant bacteria (MDRB) in colonized critical care patients attended in the medical intensive care unit (MICU) and surgical critical care unit (SCCU).

methodsObservational, unicentric study including 573 consecutive adult patients (median age of 66 years; range, 18–85 years) and comprising a total of 585 admissions. Universal MDRB screening cultures (from nasal, pharyngeal, rectal, and axillary sites) were regularly performed. Blood cultures and (semi)quantitative cultures of endotracheal or bronchoscopic specimens were performed and interpreted following consensus guidelines.

resultsColonization by MDRB was documented in 201 out of 585 admissions (34.4%), in which 261 MDRB were isolated, most frequently extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales (n = 102) followed by MDR-S. maltophilia (n = 45), carbapenemase-producing Enterobacterales (n = 40), MDR-Gram-positive bacteria (n = 35), and MDR-P. aeruginosa (n = 28). There were 21 MDRB BSI, mostly caused by Gram-negative bacteria (95.8%). Colonization by MDRB was independently associated with subsequent MDRB BSI (HR14.1; 95% CI, 3.29–60.65 P < 0.001). MDRB were recovered in 157/430 admissions requiring invasive mechanical ventilation (36.5%) and there were 25 episodes of ventilator-associated LRT infections due to MDRB, mostly MDR-Gram-negative bacteria. Colonization by MDRB was independently associated with subsequent MDRB LRT infections (HR, 6.59; 95% CI, 2.67–16.26; P < 0.001).

conclusionMDRB colonization is a significant risk factor for the occurrence of MRDB-matched invasive infections in a mixed cohort of MICU and SCCU patients. MDRB screening cultures using a multi-site sampling approach may be useful for tailoring empirical antimicrobial treatments on an individual basis.

Indexed as

BacteremiaBacteriaDrug Resistance, Multiple, BacterialPneumonia, Ventilator-AssociatedRespiratory Tract InfectionsAdolescentAdultAgedAged, 80 and overCritical CareFemaleHumansIntensive Care UnitsMaleMiddle AgedYoung AdultBacteremiaBloodstream infectionCritical care unitIntensive care unitMDRB colonizationMultidrug-resistant bacteria (MDRB)Ventilator-associated pneumoniaVentilator-associated tracheobronchitis

Identifiers

PMID41239254
PMCPMC12619235

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.