Evidence map›Paper›PMID 41239251›Full record

SynthesisBMC emergency medicine2025

Helicopter EMS for scene response to head-injured patients: systematic review & meta-analysis.

Christie L Fritz, Carlo L Rosen, Caroline E Thomas, Andy J Kim, James Price, Owen Hibberd, Sam Galvagno, David W Schoenfeld, Stephen H Thomas

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christie L Fritz *Department of Emergency Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School, One Deaconess Rd, Rosenberg 2, Boston, MA, 02215, USA. cfritz@bidmc.harvard.edu.ORCID http://orcid.org/0000-0002-0206-6164
Carlo L Rosen *Department of Emergency Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School, One Deaconess Rd, Rosenberg 2, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0002-9876-4476
Caroline E ThomasBiochemistry, Georgetown University, Washington, DC, USA.ORCID http://orcid.org/0000-0002-0953-9227
Andy J KimDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School, One Deaconess Rd, Rosenberg 2, Boston, MA, 02215, USA.ORCID http://orcid.org/0009-0005-4363-3750
James PriceEmergency and Urgent Care Research in Cambridge (EURECA), PACE Section, Department of Medicine, Cambridge University, Cambridge, UK.ORCID http://orcid.org/0000-0002-9643-692X
Owen HibberdEmergency and Urgent Care Research in Cambridge (EURECA), PACE Section, Department of Medicine, Cambridge University, Cambridge, UK.ORCID http://orcid.org/0000-0002-3839-1874
Sam GalvagnoDepartment of Anesthesiology, The University of Arizona College of Medicine - Phoenix, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0001-5563-4092
David W SchoenfeldDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School, One Deaconess Rd, Rosenberg 2, Boston, MA, 02215, USA.ORCID http://orcid.org/0009-0006-3909-3728
Stephen H ThomasDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School, One Deaconess Rd, Rosenberg 2, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0003-2833-5921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHelicopter EMS (HEMS) is an important component of prehospital trauma scene response care worldwide, including for traumatic brain injury (TBI), a major cause of mortality in injured patients. Our objective was to perform a meta-analysis (MA) of trauma HEMS scene responses to patients with severe head injury to determine whether air medical response is associated with improved survival.

methodsA broad and systematic search of the literature was conducted from the years 1970–2024. We included studies with the outcome of mortality in HEMS vs. the control of ground EMS (GEMS) in trauma scene transports (adult or pediatric) with severe TBI as defined by Glasgow Coma Score (GCS) < 9 or Head Abbreviated Injury Score (AISHead) ≥ 3. A random effects restricted maximum likelihood MA was conducted, with post-analysis evaluation for bias.

resultsOf 21 HEMS outcomes studies evaluating TBI, 15 were eligible for MA, and effect estimates were HEMS-favorable in 13 and statistically significant in 9. The null hypothesis of no HEMS association with TBI survival was rejected (p < .01) for both the GCS < 9 and the AISHead3+ groups. Heterogeneity measures supported generation of a pooled effect estimate for the GCS < 9 group: HEMS survival OR 1.37 (95% CI 1.23–1.53, I2 0%) but not for the AISHead3+ group (for which HEMS had statistically significant association with improved survival in six of eight studies, but to different degrees with resulting I2 of 93%). There were no signs of small-study (publication) or other substantial bias, with overall evaluation of moderate to low risk of bias.

conclusionsThe available evidence suggests a survival benefit associated with HEMS scene response for patients with severe head injuries as defined by GCS < 9. For this group, at the median mortality from all studies (24%), HEMS scene response to TBI saves one life for every 19 transports (95% CI for number needed to treat, 15–28).

Indexed as

Air AmbulancesBrain Injuries, TraumaticCraniocerebral TraumaEmergency Medical ServicesGlasgow Coma ScaleHumansHelicopter emergency medical serviceMortalityPrehospitalSceneTraumaTraumatic brain injury

Identifiers

PMID41239251
PMCPMC12619466

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.