ArticleBMC cancer2025
Global burden of colorectal cancer in 2022 and projections to 2050: incidence and mortality estimates from GLOBOCAN.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Resistance of Colorectal Cancer Stem Cells to Modern Therapies: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Endoscopic Hallmarks of Sessile Serrated Lesions: A Systematic Review of an Evolving Concept.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Large Language Models in Colorectal Cancer Care and Clinical Decision Support: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Systematic Review of Monocyte Transcriptomic Profiles as Diagnostic and Prognostic Biomarkers in Colorectal Cancer.International journal of molecular sciences · 2026Pooled it
- An integrated spatially defined roadmap of normal and cancer-associated colon fibroblasts.Molecular systems biology · 2026Article
- Allele-Specific MicroRNA-Binding Variants at Colorectal Cancer Risk Loci in a Hispanic/Latino Population: An Integrative GWAS, All of Us, and Epigenomic Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Article
- TAP1 deficiency reshapes tumor antigenicity and enables CD8 T cell targeting in colorectal cancer.Molecular therapy. Oncology · 2026Article
- Current status of knowledge, diagnosis and management of hereditary colorectal cancer among physicians in China: a national questionnaire survey of 81 doctors from different hospitals.Familial cancer · 2026Article
- Low-level laser irradiation stimulated tumoricidal impacts and dose-dependent modulation of Wnt signaling in three-dimensional human colorectal cancer microspheres.Lasers in medical science · 2026Article
- Green-Synthesis of Cerium Oxide Nanoparticles using Ferula Latisecta Extract: Characterization, Oxidative Stress, Autophagy, and Apoptosis Signaling in Human Colorectal Cancer Cells.Applied biochemistry and biotechnology · 2026Article
- Extracellular Vesicles Drive Invasive Characteristics and Matrix Remodelling in Organotypic Models of Colorectal Cancer Progression.Journal of extracellular biology · 2026Article
- Article
- A scoping review of virtual reality technology utilization in patients with colorectal cancer.BMC nursing · 2026Article
- Artificial Intelligence-Assisted Colonoscopy for Colorectal Lesion Detection: Current Evidence, Challenges, and Future Directions.Journal of clinical medicine · 2026Review
- Intestinal Fucosylation: A Key Regulatory Hub in Homeostasis and Disease Pathogenesis.Biomolecules · 2026Review
- Undifferentiated pelvic sarcoma 5 years post-radiochemotherapy for rectal adenocarcinoma: A case report.Oncology letters · 2026Article
- Article
- Prognostic and Diagnostic Significance of Annexin A1 in ypT3 Locally Advanced Rectal Cancer Patients.International journal of molecular sciences · 2026Article
- The EduNutriCRC Questionnaire: A Pilot Knowledge-Attitudes-Practices Study on Nutritional Prevention of Colorectal Cancer in Romanian Adults.Nutrients · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundColorectal cancer (CRC) is one of the common cancers worldwide and the second leading cause of cancer — related deaths. This study aimed to analyze the incidence and mortality of CRC in different global regions through the Global Cancer Observatory (GLOBOCAN) database, so as to provide data support for CRC prevention and treatment.
methodsIn this study, data on CRC incidence cases and deaths were extracted from the GLOBOCAN 2022 database for the world, 20 regions, and China, and age—standardized incidence rates (ASIR) and age—standardized mortality rates (ASMR) were analyzed by sex, world region, age, and human development index (HDI). Finally, the incident cases and deaths of CRC from 2022 to 2050 were predicted.
resultsData showed that in 2022, there were 1,926,425 global CRC incident cases and 904,019 deaths, with Eastern Asia having the highest numbers. China reported 517,106 incident cases and 240,010 deaths. ASIR and ASMR were higher among males than females across all regions, including China. Globally and in China, the incident cases and deaths of CRC significantly increased after the age of 40. Additionally, regions with a high HDI had higher numbers of incident and death cases of CRC, while those with a low HDI had relatively lower numbers. If CRC incidence rates remained unchanged from 2022, global new CRC cases were projected to reach 2.36 million by 2050, marking a 22.51% increase from 2022; under this same scenario of constant incidence rate, China’s new cases were estimated to decline to 464,000, representing a 10.27% decrease from 2022.
conclusionThe incidence and mortality of CRC were positively correlated with the HDI level, and gender and age were key factors affecting CRC incidence and mortality. Preventive measures needed to be taken to address the rising trends of global incidence and mortality.
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