Evidence map›Paper›PMID 41239244›Full record

ArticleBMC neurology2025

Managing paraneoplastic GABA

Mathilde Cezar, Rachele Belletto, Sara Polidori, Lisa Soive, Marco Campitiello, Pierre-Olivier Legros, Julie Egea, Francesca Plastino, Marie Benaiteau, Louise Tyvaert and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mathilde CezarDivision of Medical Oncology, CHR Metz-Thionville, 1, Allée du Château, Ars-Laquenexy, 57085, France.
Rachele BellettoDivision of Medical Oncology, Catholic University, Policlinico A. Gemelli, Largo F. Vito 8, Rome, 00136, Italy.
Sara PolidoriDivision of Medical Oncology, Catholic University, Policlinico A. Gemelli, Largo F. Vito 8, Rome, 00136, Italy.
Lisa SoiveDivision of Medical Oncology, CHR Metz-Thionville, 1, Allée du Château, Ars-Laquenexy, 57085, France.
Marco CampitielloDivision of Medical Oncology, CHR Metz-Thionville, 1, Allée du Château, Ars-Laquenexy, 57085, France.
Pierre-Olivier LegrosDivision of Medical Oncology, CHR Metz-Thionville, 1, Allée du Château, Ars-Laquenexy, 57085, France.
Julie EgeaDivision of Medical Oncology, CHR Metz-Thionville, 1, Allée du Château, Ars-Laquenexy, 57085, France.
Francesca PlastinoDivision of Medical Oncology, CHR Metz-Thionville, 1, Allée du Château, Ars-Laquenexy, 57085, France.
Marie BenaiteauDivision of Neurology, Hospital Pierre Wertheime, 59, boulevard Pinel, Lyon, 69677, France.
Louise TyvaertDivision of Neurology, CHRU de Nancy, 29, avenue du Marechal de Lattre de Tassigny, Nancy, 54000, France.
Giampaolo TortoraDivision of Medical Oncology, Catholic University, Policlinico A. Gemelli, Largo F. Vito 8, Rome, 00136, Italy.
Raffaele LongoDivision of Medical Oncology, CHR Metz-Thionville, 1, Allée du Château, Ars-Laquenexy, 57085, France. raffaele.longo@chr-metz-thionville.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGABA CASE REPORT: This case report describes a 67-year-old male with a diagnosis of SCLC who developed a paraneoplastic LE. The patient's clinical presentation included amnesia, apraxia, and mesial temporal lobe seizure. MRI showed bilateral hippocampal involvement, and cerebrospinal fluid analysis revealed elevated protein levels and GABA DISCUSSION AND

conclusionThis case highlights the difficulty and complexity of the diagnosis and management of this rare entity, particularly in cancer patients receiving ICIs. This report suggests also the potential efficacy of combining rituximab and tocilizumab and clearly demonstrates that a multidisciplinary approach, tailored to individual patient's response, is crucial for optimizing treatment outcome.

Indexed as

Antibodies, Monoclonal, HumanizedImmune Checkpoint InhibitorsLimbic EncephalitisLung NeoplasmsReceptors, GABA-BSmall Cell Lung CarcinomaAgedHumansMaleAntibodies, Monoclonal, HumanizedImmune Checkpoint InhibitorsReceptors, GABA-BtocilizumabAtezolizumabCase reportGABAB receptorLimbic encephalitisSCLC

Identifiers

PMID41239244
PMCPMC12619520

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.