Evidence map›Paper›PMID 41239224›Full record

ArticleBMC anesthesiology2025

Intensive Care management of Hemophagocytic Lymphohistiocytosis: a case series.

Riccardo Traversi, Gabriele Arrigo, Chiara Bonetto, Gabriele Sales, Alessandro Busca, Vito Fanelli, Claudia Filippini, Luca Brazzi, Giorgia Montrucchio

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Riccardo TraversiDepartment of Surgical Sciences, University of Turin, Turin, Italy. riccardo.traversi@unito.it.
Gabriele ArrigoDepartment of Surgical Sciences, University of Turin, Turin, Italy.
Chiara BonettoAnestesia e Rianimazione 1U, Department of Anesthesia, Intensive Care and Emergency, Città della Salute e della Scienza Hospital, Turin, Italy.
Gabriele SalesDepartment of Surgical Sciences, University of Turin, Turin, Italy.
Alessandro BuscaSC Ematologia, Hematopoietic Stem Cell Transplantation Center, Città della Salute e della Scienza Hospital, Turin, Italy.
Vito FanelliDepartment of Surgical Sciences, University of Turin, Turin, Italy.
Claudia FilippiniDepartment of Surgical Sciences, University of Turin, Turin, Italy.
Luca BrazziDepartment of Surgical Sciences, University of Turin, Turin, Italy.
Giorgia MontrucchioDepartment of Surgical Sciences, University of Turin, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemophagocytic Lymphohistiocytosis (HLH) is a syndrome characterized by severe hyperinflammation and immune dysfunction with concomitant immune system activation. HLH often requires supportive care management in Intensive Care Unit (ICU) with high mortality rates (36–40% of pediatric cases and 41–68% of adult cases). HLH diagnosis in ICU may be challenging due to lack of specific laboratory, radiologic and histopathologic findings, and above all the overlap of its clinical features with Multi-Organ Dysfunction syndrome (MOD). Here we present clinical characteristics, possible triggers and outcomes of a cohort of six patients admitted to our ICU for HLH or HLH-induced MOD.

methodsHere we present clinical characteristics, possible triggers and outcomes retrospectively collected of a cohort of patients admitted to our ICU for HLH or HLH-induced MOD. The study has been approved by the local ethics committee as part of the PROSAFE data collection project.

resultsSix patients were included. All but one patient had a HScore with high probability of HLH, even when not all HScore items were tested. We found infection as a potential trigger in all patients. All patients died before hospital discharge.

conclusionHLH is a condition that can overlap clinical features of septic shock. Although rare it should be considered in differential diagnosis of distributive shock without established etiology.

Indexed as

Critical CareLymphohistiocytosis, HemophagocyticAdultAgedCohort StudiesFemaleHumansIntensive Care UnitsMaleMiddle AgedMultiple Organ FailureRetrospective StudiesShock, SepticYoung Adult

Identifiers

PMID41239224
PMCPMC12619400

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