Evidence map›Paper›PMID 41239186›Full record

ArticleDiabetes/metabolism research and reviews2025

Neck Circumference and the Heart: Unveiling a New Anthropometric Marker for LVH Risk in Type 2 Diabetes-The TESEO Study.

Federica Barutta, Alessandro Andreis, Guglielmo Beccuti, Arianna Ferro, Martina Bollati, Stefania Bellini, Giulia Montesano, Giulio Mengozzi, Matteo Bellettini, Gaetano M De Ferrari and 3 more

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Article in Diabetes/metabolism research and reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Federica BaruttaDepartment of Medical Sciences, University of Turin, Turin, Italy.
Alessandro AndreisDepartment of Medical Sciences, University of Turin, Turin, Italy.
Guglielmo BeccutiDepartment of Medical Sciences, University of Turin, Turin, Italy.
Arianna FerroDepartment of Medical Sciences, University of Turin, Turin, Italy.
Martina BollatiDepartment of Medical Sciences, University of Turin, Turin, Italy.
Stefania BelliniDepartment of Medical Sciences, University of Turin, Turin, Italy.
Giulia MontesanoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Giulio MengozziDepartment of Medical Sciences, University of Turin, Turin, Italy.ORCID 0000-0003-0431-8369
Matteo BellettiniDepartment of Medical Sciences, University of Turin, Turin, Italy.
Gaetano M De FerrariDepartment of Medical Sciences, University of Turin, Turin, Italy.
Gianluca AlunniDepartment of Medical Sciences, University of Turin, Turin, Italy.
Fabio BroglioDepartment of Medical Sciences, University of Turin, Turin, Italy.
Gabriella GrudenDepartment of Medical Sciences, University of Turin, Turin, Italy.

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca Dipartimenti di Eccellenza 2018-2022 project D15D1800041000Ministero dell'Istruzione, dell'Università e della Ricerca Dipartimenti di Eccellenza 2024-2026 UNITO-ECC_D223; AI4MENovo Nordisk Sponsor n1/2021Università degli Studi di Torino
6 · The paper itself

Abstract

aimLeft ventricular hypertrophy (LVH) is highly prevalent among individuals with type 2 diabetes (T2DM) and is a predictor of adverse cardiovascular outcomes. Visceral and ectopic fat accumulation contributes to cardiometabolic risk. Neck circumference (NC) and the neck circumference-to-height index (NCI) have emerged as potential markers of ectopic adiposity, yet their association with LVH remains unexplored. The aim of this study was to evaluate the relationship between NC and NCI with the presence of LVH in a contemporary cohort of T2DM patients. MATERIALS AND

methodsT2DM patients were consecutively enroled in the TESEO study. Participants underwent comprehensive clinical, biochemical, bioimpedance and echocardiographic evaluations. Multivariable logistic regression models were used to examine the independent associations between NC/NCI and LVH, adjusting for age, sex, mean arterial blood pressure, HbA1c, triglycerides, estimated glomerular filtration rate, urinary albumin-to-creatinine ratio and treatments.

results29% of participants had LVH. NC and NCI were higher among individuals with LVH. After full adjustment, NC and NCI were independently associated with 26% and 57% higher odds of LVH, respectively. Stratified analyses revealed a stronger association in men (OR 1.65, 95% CI: 1.25-2.18) than in women (OR 1.49, 95% CI: 1.19-1.87). NC and NCI outperformed BMI and waist circumference in their association with LVH. ROC curve analyses confirmed that NCI has good discriminatory power for identifying individuals with and without LVH.

conclusionsNC and NCI are independently associated with LVH in T2DM patients and they may represent practical, non-invasive markers to enhance cardiovascular risk stratification in clinical settings.

Indexed as

AnthropometryBiomarkersDiabetes Mellitus, Type 2Hypertrophy, Left VentricularNeckAgedCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRisk FactorsBiomarkersleft ventricular hypertrophyneck circumferenceneck circumference to height ratiotype 2 diabetes

Identifiers

PMID41239186
PMCPMC12618759

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