SynthesisJournal of gastrointestinal cancer2025
Misdiagnosis of Suspected Cancer in Pancreatoduodenectomy: A Systematic Review and Prevalence Mata-Analysis.
Synthesis in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Diagnostic algorithm for the imaging evaluation of a solid pancreatic mass: is it malignant?Abdominal radiology (New York) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferentiating between pancreatic cancer (PC) and benign pancreatic lesions is challenging, leading to misdiagnosis and unnecessary pancreatoduodenectomy (PD). This systematic review and meta-analysis aimed to determine the prevalence of PC misdiagnosis in PD.
methodsA systematic review was conducted following PRISMA guidelines and was prospectively registered on PROSPERO (CRD42024510669). We included 21 studies comprising 13,660 patients who underwent PD for suspected malignancy. A random-effects meta-analysis with 95% confidence interval (CI) was used to calculate the pooled prevalence of misdiagnosis and risk ratios of surgical complications or clinical manifestations.
resultsThe pooled prevalence of misdiagnosed cancer cases was 8.35% (95% CI: 7.26-9.59). Chronic pancreatitis was the most common benign condition mistaken for cancer, with a pooled prevalence of 40.69% (95% CI 28.47-58.15). The most frequently reported preoperative symptoms included abdominal pain (62.54%), jaundice (52.05%), and weight loss (52.71%). Misdiagnosis was associated with abdominal pain as a clinical presentation, whereas jaundice was more common in malignancy (OR 2.21, 95% CI 1.15-4.24). Malignant pathology was associated with higher risks of postoperative pancreatic fistula (RR 2.01, 95% CI 1.18-3.43) and mortality (RR 2.57, 95% CI 1.06-6.24). Misdiagnoses were more prevalent among younger male patients, with females comprising 39.86% (95% CI 31.18-46.48) of the cohort. DISCUSSION: Pancreatic cancer misdiagnosis leading to surgical intervention remains a prevalent condition, with young male patients without weight loss being the most affected population and chronic pancreatitis the major differential diagnosis.
Indexed as
Identifiers
41239143What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.