ArticleMolecular neurobiology2025
HAT p300/CBP Activity in the Prelimbic Cortex Underlies Reconsolidation of Contextual Fear Memory.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Reconsolidation, a memory stabilization phase occurring after reactivation, depends on epigenetic mechanisms such as histone acetylation, mediated by histone acetyltransferases (HATs) like p300/CBP. The prelimbic (PL) region of the medial prefrontal cortex is involved in fear memory reconsolidation, whereas the infralimbic (IL) cortex supports memory extinction. In the PL cortex, epigenetic mechanisms mediated by HAT CBP have been implicated in fear discrimination. However, the role of HAT p300/CBP in PL and IL cortices during contextual fear memory reconsolidation is unknown. To investigate this, fear-conditioned animals received intra-PL or IL cortices administration of C646 (5 or 50 ng/0.2uL/side), a HAT p300/CBP inhibitor, immediately, 1 h, or 6 h after memory reactivation. In the PL cortex, C646 (50 ng) administered within 1 h post-reactivation disrupted reconsolidation, evidenced by reduced freezing in Test A
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