Evidence map›Paper›PMID 41239131›Full record

ArticleCell regeneration (London, England)2025

Posterior enhancer (p-Enh) maintains early neuromesodermal progenitors bi-potency during gastrulation.

Panpan Mi, Yingying Chen, Fengxiang Tan, Penglei Shen, Yun Yang, Mingzhu Wen, Yun Qian, Jichang Wang, Naihe Jing, Xianfa Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell regeneration (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Panpan Mi *Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Yingying Chen *Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou , Guangdong, 510005, China. chen_yingying@gzlab.ac.cn.
Fengxiang Tan *Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou , Guangdong, 510005, China.
Penglei ShenGuangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou , Guangdong, 510005, China.
Yun YangGuangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou , Guangdong, 510005, China.
Mingzhu WenGuangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou , Guangdong, 510005, China.
Yun QianState Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Jichang WangDepartment of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. wangjch53@mail.sysu.edu.cn.
Naihe JingGuangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou , Guangdong, 510005, China. jing_naihe@gzlab.ac.cn.ORCID http://orcid.org/0000-0003-1509-6378
Xianfa YangGuangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou , Guangdong, 510005, China. yang_xianfa@gzlab.ac.cn.

Funding

Major Project of Guangzhou National Laboratory GZNL2023A02005Major Project of Guangzhou National Laboratory GZNL2025C02014National Key Basic Research and Development Program of China 2018YFA0800100National Key Basic Research and Development Program of China 2019YFA0801402National Key Basic Research and Development Program of China 2025YFE0200600National Natural Science Foundation of China 31900454National Natural Science Foundation of China 32130030National Natural Science Foundation of China 32470866Union Project by Guangzhou National Laboratory and State Key Laboratory of Respiratory Disease, Guangzhou Medical University GZNL2024B01007
6 · The paper itself

Abstract

Vertebrate axis patterning requires precise control of the differentiation of neuromesodermal progenitors (NMPs), which generate spinal cord (SC) and presomitic mesoderm (PSM). Previously, we identified a gastrula-premarked posterior enhancer (p-Enh) that is essential for posterior tissue development by regulating somite and SC in organogenetic embryos, while its role in early NMPs cells remains elusive. Here, using a highly efficient in vitro differentiation system, we found that the genetic removal of p-Enh leads to the aberrantly up-regulated PSM-related genes during both PSM and SC differentiation. Time-resolved transcriptomic analysis and experimental characterization revealed the activated PSM transcriptomic signature arose from disorganized NMPs composition, with an over-representation of the T

Indexed as

Cell fate determinationEnhancerGastrulationNeuromesodermal progenitorsST-Pheno

Identifiers

PMID41239131
PMCPMC12618760

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.