Evidence map›Paper›PMID 41239106›Full record

ArticleMolecular neurobiology2025

Inhibition of PDE4 Alleviates Endoplasmic Reticulum Stress and Neuronal Damage via Activation of Nrf2/HO-1 in Parkinson's Disease.

Jiahong Zhong, Yunyun Qin, Junling Xue, Qiuming Wang, Xiaochun Lin, Guozhu Tan, Huilin Xiao, Xihui Yu, Zhuomiao Lin

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiahong Zhong *Department of Clinical Pharmacy, Meizhou People's Hospital (Huangtang Hospital), Meizhou, 514031, Guangdong, China.
Yunyun Qin *Department of Pharmacy, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530000, Guangxi, China.
Junling Xue *Department of Pharmacy, The Second Affiliated Hospital of Shantou University Medical College, Shantou, 515000, Guangdong, China.
Qiuming WangDepartment of Clinical Pharmacy, Meizhou People's Hospital (Huangtang Hospital), Meizhou, 514031, Guangdong, China.
Xiaochun LinDepartment of Clinical Pharmacy, Guangzhou First People's Hospital, Guangzhou, 510000, Guangdong, China.
Guozhu TanDepartment of Orthopaedics and Traumatology, The Seventh Affiliated Hospital, Southern Medical University, Foshan, 528000, Guangdong, China.
Huilin XiaoSchool of Public Health, Guangdong Medical University, Dongguan, 523000, Guangdong, China.
Xihui YuDepartment of Pharmacy, The Second Affiliated Hospital of Shantou University Medical College, Shantou, 515000, Guangdong, China. xihuiyu2016@163.com.
Zhuomiao LinDepartment of Clinical Pharmacy, Meizhou People's Hospital (Huangtang Hospital), Meizhou, 514031, Guangdong, China. linzhuomiao@mzrmyy.com.

Funding

China Postdoctoral Science Foundation 2022M713263GuangDong Basic and Applied Basic Research Foundation 2023A1515111199National Nature Science Foundation of China 82304434Scientific Research Starting Foundation for High-level Talents of Meizhou People's Hospital KYQD202501, KYQD202502Shining Across China-Medicinal Research Fund Z04J2023E095Social Development Science and Technology Plan Project of Meizhou 2024C0301079
6 · The paper itself

Abstract

Parkinson's disease (PD) is a typical neurodegenerative disorder characterized by the aggregation of pathological α-synuclein. The accumulation of misfolded proteins can induce severe endoplasmic reticulum stress (ERS) and lead to neuronal damage. In this study, we investigated the effects of phosphodiesterase 4 (PDE4) inhibitors on ER homeostasis in a PD model. In vitro experiments using SH-SY5Y cells demonstrated that treatment with 1-methyl-4-phenylpyridinium ion (MPP

Indexed as

Cyclic Nucleotide Phosphodiesterases, Type 4Endoplasmic Reticulum StressHeme Oxygenase-1NeuronsNF-E2-Related Factor 2Parkinson DiseasePhosphodiesterase 4 Inhibitors1-Methyl-4-phenylpyridiniumAnimalsCell Line, TumorHumansMaleMiceMice, Inbred C57BL1-Methyl-4-phenylpyridiniumCyclic Nucleotide Phosphodiesterases, Type 4Heme Oxygenase-1NF-E2-Related Factor 2Phosphodiesterase 4 InhibitorsEndoplasmic reticulum stressMPP+Nrf2/HO-1Parkinson's diseasePDE4

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.