Effect of food on iron absorption in patients with iron deficiency anemia treated with ferric citrate hydrate.

Norio Komatsu, Kyoko Ito, Kojo Arita, Yuko Mitobe, Hironori Mitsui

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in International journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Norio KomatsuDepartment of Hematology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. komatsun@juntendo.ac.jp.ORCID https://orcid.org/0000-0003-1880-9126

Kyoko ItoMedical Affairs Department, Torii Pharmaceutical Co., Ltd., 3-4-1, Nihonbashi-Honcho, Chuo-Ku, Tokyo, 103-8439, Japan.ORCID https://orcid.org/0000-0003-3258-4429

Kojo AritaClinical Development Department, Pharmaceutical Division, Japan Tobacco Inc., 3-4-1, Nihonbashi-Honcho, Chuo-ku, Tokyo, 103-0023, Japan.ORCID https://orcid.org/0009-0006-5020-8944

Yuko MitobeMedical Affairs Department, Torii Pharmaceutical Co., Ltd., 3-4-1, Nihonbashi-Honcho, Chuo-Ku, Tokyo, 103-8439, Japan.ORCID https://orcid.org/0000-0001-8897-8561

Hironori MitsuiClinical Development Department, Pharmaceutical Division, Japan Tobacco Inc., 3-4-1, Nihonbashi-Honcho, Chuo-ku, Tokyo, 103-0023, Japan. hironori.mitsui@jt.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron absorption after the administration of oral iron preparations following a meal is generally reduced compared with fasting. The aim of this study was to investigate the effect of food on iron absorption following ferric citrate hydrate administration in patients with iron deficiency anemia. A randomized, open-label, two-cohort, two-period, single-dose crossover study was conducted to assess the effect of food on iron absorption when 500 mg ferric citrate hydrate (approximately 120 mg of ferric iron) was administered under fasted and fed (immediately after a meal) conditions. Twelve patients aged 20-45 years with iron deficiency anemia (hemoglobin: male 8.0-13.0 g/dL, female 8.0-12.0 g/dL; serum ferritin < 12 ng/mL; transferrin saturation ≤ 16%), participated. The maximum serum iron concentration change was defined as ΔC

Indexed as

Anemia, Iron-DeficiencyFerric CompoundsFood-Drug InteractionsIronAdultCross-Over StudiesFastingFemaleHumansIntestinal AbsorptionMaleMiddle AgedYoung Adultferric citrateFerric CompoundsIronCrossover studyFerric citrate hydrateFood effectIron absorptionIron deficiency anemia

Identifiers

PMID41239076

DOI10.1007/s12185-025-04108-8

PMCPMC12967394

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.