ReviewJournal of assisted reproduction and genetics2026
The effect of gender-affirming testosterone therapy on ovarian function and oocyte quality in transgender men: a literature review.
Review in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTransgender men (TGM) are individuals who identify as males but were assigned female sex at birth. Gender-affirming testosterone therapy (GATT) is used to induce virilization, and its effects on fertility are discussed. To provide TGM with complete fertility counseling, we synthesized data concerning the impact of GATT on ovarian reserve and oocyte quality.
methodsWe conducted a narrative review of published data on the ovarian and oocyte features induced by GATT in TGM.
resultsData on ovarian morphology and histology showed a normal proportion of primordial, primary, pre-antral, and antral follicles, and a significantly higher number of atretic and cystic follicles. Additionally, ovaries exhibited diffuse ovarian stromal hyperplasia and a thicker ovarian cortex, tunica albuginea, and basal membrane. No impact on ovarian reserve was observed. Oocyte quality following ovarian stimulation did not appear to be impaired and led to the birth of healthy offspring.
conclusionThese findings may reassure transgender patients and their care providers that satisfactory reproductive outcomes are possible, even if GATT has already been initiated. However, further investigation is needed to assess the reversibility and functional impact of these changes on ovarian folliculogenesis, ART success rates, pregnancy, and child health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.