Evidence map›Paper›PMID 41238930›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Smilax china L. Polysaccharide Alleviates HFD-induced Insulin Resistance via Modulating Gut Microbiota and AMPK/PI3K/AKT Signaling Pathway in Mice.

Wenjing Wang, Jiaxin Wang, Xinru Hu, Peiqin Chen, Yuqi Cheng, Jingen Li, Guodong Zheng

Abstract read
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In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenjing WangCollege of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi Province, 330045, P.R. China.
Jiaxin WangCollege of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi Province, 330045, P.R. China.
Xinru HuCollege of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi Province, 330045, P.R. China.
Peiqin ChenCollege of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi Province, 330045, P.R. China.
Yuqi ChengCollege of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi Province, 330045, P.R. China.
Jingen LiCollege of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi Province, 330045, P.R. China. enen928@163.com.
Guodong ZhengCollege of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi Province, 330045, P.R. China. zrs150716@aliyun.com.

Funding

National Natural Science Foundation of China No. 82060165
6 · The paper itself

Abstract

Insulin resistance (IR) is a risk factor for numerous metabolic diseases, presenting a significant public health challenge. Smilax china L. polysaccharide (SCP) has been reported to possess anti-obesity properties. However, the effect of SCP on high-fat diet (HFD)-induced IR in mice remains unclear. In this study, a mouse model of HFD-induced IR was established, and SCP intervention was administered. The effects of SCP on IR were comprehensively evaluated using biochemical indicators, histopathological analysis, 16S rRNA sequencing, non-targeted metabolomics analysis, and RT-qPCR analysis. SCP significantly reduced serum glucose and lipid levels while alleviating liver damage. Moreover, SCP remodeled the gut microbiota structure by increasing the relative abundance of Kineothrix, Bacteroides, and Alloprevotella, while suppressing the proliferation of Erysipelatoclostridium, Ruminococcus, and Streptococcus. SCP also elevated the levels of pyridoxal, kynurenine, and lecithin. At the molecular level, SCP upregulated the gene expression of AMPK, PI3K, and AKT in both liver and adipose tissue. In summary, SCP may alleviate HFD-induced IR by modulating the gut microbiota and the AMPK/PI3K/AKT signaling pathway, thereby providing a theoretical basis for SCP-based therapeutic strategies in IR treatment and opening new avenues for the nutritional management of metabolic diseases.

Indexed as

Gastrointestinal MicrobiomeInsulin ResistancePolysaccharidesSmilaxAMP-Activated Protein KinasesAnimalsDiet, High-FatLiverMaleMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionAMP-Activated Protein KinasesPhosphatidylinositol 3-KinasesPolysaccharidesProto-Oncogene Proteins c-aktAMPK/PI3K/AKT signaling pathwayGut microbiotaInsulin resistanceSmilax china L. polysaccharide

Identifiers

PMID41238930

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.