ArticlePediatric research2026
Exploring hemoglobin dynamics and scavenging mechanisms in preterm infants and preterm rabbits with cerebral intraventricular hemorrhage.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Transcriptomic Challenges We Faced with Animal Models for Neurological Disorders.Current issues in molecular biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraventricular hemorrhage (IVH) is a leading cause of neurodevelopmental impairment in preterm infants, driven by vascular rupture, intraventricular blood accumulation, and secondary injury. Hemolysis releases extracellular hemoglobin (Hb) into the cerebrospinal fluid (CSF), where it promotes oxidative stress, inflammation, and cytotoxicity. The endogenous Hb-scavenging protein haptoglobin (Hp) may mitigate Hb-mediated injury, but its capacity in the immature brain remains unclear. This study aimed to characterize Hb and Hp dynamics in the CSF of preterm infants with severe IVH and to evaluate the translational utility of a preterm rabbit glycerol-induced IVH model.
methodsFourteen infants with grade III IVH or periventricular hemorrhagic infarction were enrolled in a prospective study. CSF was collected via ventricular access devices and analyzed alongside samples from rabbit pups with induced IVH.
resultsInfants showed markedly elevated CSF Hb (mean ± SEM: 133.3 ± 50.1 µmol/L, heme equivalents) and low Hp (0.87 ± 0.15 µg/mL). Similar patterns were observed in IVH-exposed rabbit pups, with elevated Hb and significantly reduced CSF Hp compared to non-IVH controls.
conclusionThese findings indicate a persistent deficit in endogenous Hb clearance following IVH and demonstrate that the rabbit pup model closely reflects the human condition, making it well-suited for preclinical evaluation of Hb-scavenging therapies. IMPACT: The aim of this study was to characterize the dynamics of hemoglobin and haptoglobin in the cerebrospinal fluid of preterm infants with severe IVH and to evaluate the translational validity of a preterm rabbit pup IVH model. By directly comparing hemoglobin and haptoglobin concentrations across species, this study revealed a profound imbalance between hemoglobin burden and scavenging capacity, highlighting a persistent deficit in endogenous clearance. These findings provide a strong rationale for therapeutic strategies targeting hemoglobin clearance in preterm IVH and support the use of the rabbit pup IVH model for translational studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.