Evidence map›Paper›PMID 41238898›Full record

ArticleCell death and differentiation2026

LINC 02086, a novel biomarker for early detection of gastric cancer and a target for cancer therapy.

Kaiyue Sun, Liping Gong, Jianbo Liu, Yanting Liu, Yikun Li, Jiahao Zhang, Ruijie Ma, Hongqian Zhang, Xue Gao, Chuanxu Yang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. H2AC19 promotes lung adenocarcinoma progressionActa pharmaceutica Sinica. B · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kaiyue SunDepartment of Physiology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Liping GongDepartment of General Practice, The Second Qilu Hospital of Shandong University, Jinan, Shandong, China.
Jianbo LiuDepartment of Physiology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Yanting LiuDepartment of Physiology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Yikun LiDepartment of Physiology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Jiahao ZhangDepartment of Physiology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Ruijie MaDepartment of Physiology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Hongqian ZhangKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, and School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
Xue GaoKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, and School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
Chuanxu YangKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, and School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
Yunshan WangDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.ORCID http://orcid.org/0000-0001-5234-8752
Xiuqin WangDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Xia WangDepartment of Physiology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Dawei ChenInstitute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Huili HuThe Key Laboratory of Experimental Teratology, Ministry of Education, Department of Systems Biomedicine, Research Center of Stem Cell and Regenerative Medicine, School of Basic Medical Sciences, Shandong University, Jinan, China.ORCID http://orcid.org/0000-0002-1269-1887
Hongjuan WangDepartment of Gastroenterology, The Second Qilu Hospital of Shandong University, Jinan, Shandong, China. wanghongjuan78@126.com.ORCID http://orcid.org/0009-0009-9168-5562
Wei GuoDepartment of Colorectal Surgery, Department of General Surgery, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China. wguo@sdu.edu.cn.ORCID http://orcid.org/0000-0001-8405-832X
Jingxin LiDepartment of Physiology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. ljingxin@sdu.edu.cn.ORCID http://orcid.org/0000-0001-7370-703X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) remains a significant global health challenge, often diagnosed at advanced stages due to the absence of reliable early detection biomarkers. In this study, we collected serum samples from multicenter, demonstrating elevated serum levels of LINC 02086 exhibit high diagnostic accuracy. LINC 02086 significantly upregulated in GC tissues, with its expression correlating with poor patient survival. As a driving factor of GC, Helicobacter pylori infection upregulates LINC 02086. Mechanistically, we found METTL3-mediated N6-methyladenosine modification of LINC 02086 promotes GC progression, which upregulates HuR by sponging miRNA-139. We also explored the therapeutic potential of LINC 02086-targeted siRNA delivered via lipid nanoparticles, showing significant inhibition of GC growth and metastasis. These findings position LINC 02086 as a promising serum biomarker for early GC detection and as a potential therapeutic target, paving the way for improved diagnostic and treatment strategies in GC.

Indexed as

Biomarkers, TumorEarly Detection of CancerRNA, Long NoncodingStomach NeoplasmsAnimalsCell Line, TumorCell ProliferationELAV-Like Protein 1FemaleGene Expression Regulation, NeoplasticHelicobacter InfectionsHumansMaleMethyltransferasesMiceMice, NudeBiomarkers, TumorELAV-Like Protein 1MethyltransferasesMETTL3 protein, humanMicroRNAsRNA, Long Noncoding

Identifiers

PMID41238898
PMCPMC13076605

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.