Evidence map›Paper›PMID 41238793›Full record

ArticleCellular & molecular immunology2025

FOXO1-driven metabolic reprogramming of hematomal CD8

Jie Lin, Honglei Ren, Youliang Wang, Hanzhi Yu, Zhili Chen, Xintong Yu, Zhuyu Gao, Yan Zheng, Quanhong Wu, Yizhe Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jie Lin *Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China.
Honglei Ren *Department of Neurology, Tianjin Neurological Institute, Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, International Joint Laboratory of Ocular Diseases, Ministry of Education, Haihe Laboratory of Cell Ecosystem, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Youliang Wang *Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China.
Hanzhi Yu *Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.
Zhili ChenDepartment of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China.
Xintong YuDepartment of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China.
Zhuyu GaoDepartment of Neurosurgery of First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Yan ZhengDepartment of Neurosurgery of First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
Quanhong WuDepartment of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China.
Yizhe ZhangDepartment of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China.
Qijian LinDepartment of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China.
Rui LiDepartment of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China.ORCID 0000-0002-7210-8358
Decai TianChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Zhigang CaiDepartment of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.
Qiang LiuDepartment of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China. qliu@tmu.edu.cn.
Ying FuDepartment of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China. fuying@fjmu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82101373National Natural Science Foundation of China (National Science Foundation of China) 82171284National Natural Science Foundation of China (National Science Foundation of China) 82200279National Natural Science Foundation of China (National Science Foundation of China) 82225015National Natural Science Foundation of China (National Science Foundation of China) 82371349National Natural Science Foundation of China (National Science Foundation of China) U21A20360
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) causes hematoma formation, leading to PHE, which is associated with leukocyte mobilization and increased inflammation at the site of brain injury. However, the fate of accumulated leukocytes within the hematoma and their impact on PHE expansion remain unknown. We performed single-cell immune profiling of hematoma cells from patients with acute ICH and reported a distinct phenotypic transformation of CD8

Indexed as

Brain EdemaCD8-Positive T-LymphocytesCellular ReprogrammingCerebral HemorrhageForkhead Box Protein O1HematomaAnimalsFemaleHumansInterferon-gammaMaleMetabolic ReprogrammingMiceMice, Inbred C57BLMicrogliaForkhead Box Protein O1FOXO1 protein, humanInterferon-gammaCD8+ T cellsHematomaIntracerebral hemorrhageNeuroinflammationPerihematomal edema

Identifiers

PMID41238793
PMCPMC12660799

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.