Evidence map›Paper›PMID 41238755›Full record

ReviewNature reviews. Microbiology2026

The gut microbiome shapes social behaviour across animal species.

Jessica A Griffiths, Khemlal Nirmalkar, Wei-Li Wu, Rosa Krajmalnik-Brown, Sarkis K Mazmanian

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica A GriffithsDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. jgriffit@caltech.edu.ORCID http://orcid.org/0000-0002-5586-1567
Khemlal NirmalkarBiodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, USA.ORCID http://orcid.org/0000-0001-6732-9175
Wei-Li WuDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0000-0003-2610-1881
Rosa Krajmalnik-BrownBiodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, USA.ORCID http://orcid.org/0000-0001-6064-3524
Sarkis K MazmanianDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. sarkis@caltech.edu.ORCID http://orcid.org/0000-0003-2713-1513

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiome has profound influences on brain activity and complex behaviours. Research across diverse animal species, in both natural environments and laboratory settings, has identified biological mechanisms that underlie gut-brain interactions. An emerging central theme is that the gut microbiome is shaped by, and actively contributes to, sociability throughout the lifespan. In this Review, we highlight recent literature revealing the effects of the microbiome on early neurodevelopment, immune modulation, stress responses and microorganism-mediated metabolism that affect social behaviour. Studies investigating the cellular and molecular pathways that underlie microbial influences on social behaviour have implicated brain regions and circuits that mediate critical aspects of animal behaviours, including bonding, mating, defence, aggression and social learning. Gut microbiome-brain research using animal models of social deficits and ecological studies in the wild, as well as investigations of human conditions comorbid with impaired social behaviour, could offer new and natural avenues for improved quality of life in individuals and social groups.

Indexed as

Behavior, AnimalGastrointestinal MicrobiomeSocial BehaviorAnimalsBrainHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.