Evidence map›Paper›PMID 41238748›Full record

ReviewNature microbiology2025

Exploring the concept of bacterial memory.

Killian Scanlon, Fergus Shanahan, R Paul Ross, Colin Hill

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Killian ScanlonAPC Microbiome Ireland, Biosciences Institute, University College, Cork, Ireland.
Fergus ShanahanAPC Microbiome Ireland, Biosciences Institute, University College, Cork, Ireland.ORCID http://orcid.org/0000-0003-0467-0936
R Paul RossAPC Microbiome Ireland, Biosciences Institute, University College, Cork, Ireland.ORCID http://orcid.org/0000-0003-4876-8839
Colin HillAPC Microbiome Ireland, Biosciences Institute, University College, Cork, Ireland. c.hill@ucc.ie.ORCID http://orcid.org/0000-0002-8527-1445

Funding

Science Foundation Ireland (SFI) SFI/12/RC/2273_P2
6 · The paper itself

Abstract

Bacteria have multiple mechanisms through which they sense changes in their environment and respond appropriately. In some instances, bacteria appear to retain an imprint of past events that can influence future behaviour, resembling a form of memory. This Perspective explores this concept of bacterial memory at the genetic, epigenetic, biochemical and ecological levels. We discuss how memory can prime bacteria to respond appropriately to recurring stimuli, providing fitness benefits in fluctuating environments. At the cellular level, there is evidence for memory storage mechanisms involving mutations, DNA methylation, or the inheritance of metabolites or proteins that provide a means of accessing past experiences. Complex bacterial communities can exhibit ecological memories of past environments, stored as microbiota population changes that persist or lag after acute environmental change. We review the emerging evidence supporting these concepts of microbial memory, outline some of the key molecular mechanisms, and identify research gaps and potential future applications.

Indexed as

BacteriaBacterial Physiological PhenomenaDNA MethylationEpigenesis, GeneticMicrobiotaMutation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.