ArticleScientific reports2025
Detailed atomistic investigation of aggregation and interaction of teriparatide in aqueous media.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Antimicrobial peptides as computational candidates for SARS-CoV-2 papain-like protease inhibition.Scientific reports · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Teriparatide (TPTD), a recombinant peptide used in osteoporosis treatment, exhibits self-association that may lead to immunogenicity and reduced therapeutic efficacy. To investigate its aggregation behavior, we performed molecular dynamics simulations of systems containing 1, 5, and 10 TPTD molecules in water, assessing concentration-dependent effects. Structural and dynamic properties were analyzed using root-mean-square deviation, free energy landscapes, secondary structure probabilities, and Kirkwood-Buff integrals derived from radial distribution functions. The simulations reveal key intermolecular interactions and conformational preferences that drive TPTD self-assembly. Water-mediated hydrogen bonding and hydrophobic contacts were found to modulate aggregation, with notable structural compaction at higher concentrations. These findings provide mechanistic insight into TPTD aggregation and offer guidance for minimizing immunogenic risks in peptide-based therapeutics.
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