Evidence map›Paper›PMID 41238360›Full record

ArticleBMJ open2025

Scale-up of a paediatric HIV disclosure intervention in Ghana using a stepped wedge cluster randomised trial design: Sankofa 2 protocol and implementation.

Nancy R Reynolds, Veronika Shabanova, Lorna Renner, Sampson Antwi, Stephen Ayisi Addo, Anthony K Enimil, Margaret Lartey, Geliang Gan, Stephen Parziale, Kofi Aikins Amissah and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04791865 (Pediatric HIV Disclosure Benefits Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04791865 nacompletednot on this map

Pediatric HIV Disclosure Benefits Study (PhD-BS) - Sankofa 2

TypeinterventionalSponsorBoston UniversityRan2021 to 2025Enrolled748ConditionsHIVArmsDisclosure intervention, Usual Care
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nancy R ReynoldsJohns Hopkins University, Baltimore, Maryland, USA nancy.reynolds@jhu.edu.ORCID http://orcid.org/0000-0002-5023-1953
Veronika ShabanovaYale University, New Haven, Connecticut, USA.
Lorna RennerUniversity of Ghana, Accra, Greater Accra Region, Ghana.
Sampson AntwiKwame Nkrumah University of Science and Technology, Kumasi, Ashanti Region, Ghana.
Stephen Ayisi AddoGhana Health Service, Accra, Greater Accra Region, Ghana.
Anthony K EnimilKwame Nkrumah University of Science and Technology, Kumasi, Ashanti Region, Ghana.
Margaret LarteyUniversity of Ghana, Accra, Greater Accra Region, Ghana.
Geliang GanYale University, New Haven, Connecticut, USA.
Stephen ParzialeYale University, New Haven, Connecticut, USA.
Kofi Aikins AmissahKwame Nkrumah University of Science and Technology, Kumasi, Ashanti Region, Ghana.
Jonas T KusahUniversity of Ghana, Accra, Greater Accra Region, Ghana.
Angela L Ofori-AttaUniversity of Ghana, Accra, Greater Accra Region, Ghana.
Eric SladeJohns Hopkins University, Baltimore, Maryland, USA.
Thomas Agyarko-PokuGhana Health Service, Accra, Greater Accra Region, Ghana.
Elijah PaintsilYale University, New Haven, Connecticut, USA.

Funding

Pediatric HIV Disclosure Intervention and Benefits Study-(PH-DIBS)R01HD103512 · NICHD · YALE UNIVERSITY · PI PAINTSIL, ELIJAH, REYNOLDS, NANCY R · 2020 to 2024
$3.4M
NICHD NIH HHS R01 HD103512
6 · The paper itself

Abstract

introductionThere is a pressing need for effective interventions that can support healthcare workers and caregivers in the challenging yet crucial task of disclosing the HIV status to infected children and adolescents. Previously, we developed and tested a successful disclosure intervention called Sankofa in Ghana. In an ongoing 5-year follow-up study, Sankofa 2, we aim to build on the successful Sankofa trial by testing the intervention on a larger scale. METHODS AND ANALYSIS: This study is a pragmatic, stepped-wedge cluster randomised trial.

settingIt is being conducted in 12 HIV paediatric clinics in Ghana to examine the effectiveness, health benefits, cost and implementation of the Sankofa intervention. Caregiver-child dyads (n=700) will be enrolled. Evaluation of effectiveness, health benefits, cost and implementation of the Paediatric HIV disclosure intervention, Sankofa 2, is posed to offer valuable insights for scale-up and sustainability. ETHICS AND DISSEMINATION: Ethical clearance has been obtained from the Ghana Health Service Ethics Review Committee, the University of Ghana Ethical and Protocol Review Committee, the Committee on Human Research Publication and Ethics of the Kwame Nkrumah University of Science and Technology, the Johns Hopkins Medicine Institutional Review Board and the Yale School of Medicine Human Investigation Committee. The clinical trial was registered on ClinicalTrials.gov on 5 March 2021. All caregiver participants are required to provide written informed consent and the children assent before enrolment. If either the child or caregiver says no to the study, the dyad is not eligible for the study. No study-related procedures are performed until consent is obtained. The results of the trial will be added on ClinicalTrials.gov, published in peer-reviewed journals and presented at international conferences. TRIAL REGISTRATION NUMBER: NCT04791865.

Indexed as

CaregiversHIV InfectionsTruth DisclosureAdolescentChildChild, PreschoolCost-Benefit AnalysisFemaleGhanaHumansMalePragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicResearch DesignAdolescentClinical TrialImplementation Science

Identifiers

PMID41238360
PMCPMC12625916

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.