Evidence map›Paper›PMID 41238081›Full record

ArticleThe Journal of infection2025

Plasmodium falciparum gene expression signatures and antibody profiling implicate the fikk, phist, and surf multigene families in severe malaria syndromes.

Bryan E Cummings, Emily M Stucke, Drissa Coulibaly, Jonathan G Lawton, Rafal S Sobota, Abdoulaye Kassoum Kone, Bourama Kane, Bouréima Guindo, Bourama Tangara, Mody Sissoko and 31 more

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PubMed Full text at PMC Publisher
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Article in The Journal of infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Bryan E CummingsMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA.
Emily M StuckeMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA.
Drissa CoulibalyMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Jonathan G LawtonMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA.
Rafal S SobotaMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA; Ken and Ruth Davee Department of Neurology, Northwestern University, 303 E. Chicago Avenue, Chicago, IL, USA.
Abdoulaye Kassoum KoneMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Bourama KaneMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Bouréima GuindoMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Bourama TangaraMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Mody SissokoMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Fayçal MaigaMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Karim TraoreMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Aichatou DiawaraMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Amidou TraoreMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Ali TheraMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Antoine DaraMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Amadou NiangalyMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Modibo DaouMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Issa DiarraMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Youssouf ToloMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Savy SebastianMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA.
Aarti JainVaccine Research & Development Center, University of California, 825 Health Sciences Road, Irvine, CA, USA.
Rie NakajimaVaccine Research & Development Center, University of California, 825 Health Sciences Road, Irvine, CA, USA.
Algis JasinskasVaccine Research & Development Center, University of California, 825 Health Sciences Road, Irvine, CA, USA.
Emily K SilzelVaccine Research & Development Center, University of California, 825 Health Sciences Road, Irvine, CA, USA.
Biraj ShresthaMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA.
Amed OuattaraMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA.
James B MunroInstitute for Genome Sciences, University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD, USA.
Matthew B LaurensMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA.
Kirsten E LykeMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA.
Kieran TebbenInstitute for Genome Sciences, University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD, USA.
Haikel BogaleInstitute for Genome Sciences, University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD, USA.
Christopher V PloweMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA.
Mahamadou S SissokoMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Bourema KouribaMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Shannon Takala-HarrisonMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA.
Philip L FelgnerVaccine Research & Development Center, University of California, 825 Health Sciences Road, Irvine, CA, USA.
Joana C SilvaInstitute for Genome Sciences, University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD, USA.
Ogobara K DoumboMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Mahamadou A TheraMalaria Research and Training Center, University of Sciences, Techniques and Technologies, BP 1805, Point G, Bamako, Mali.
Mark A TravassosMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD, USA. Electronic address: mtravass@som.umaryland.edu.

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUNNING HOTOPP, JULIE · 2014 to 2023
$36.5M
University of Maryland FIRST ProgramU54CA272205 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI JAMES B KAPER, William Richard LaCourse · 2022 to 2026
$18.1M
FELLOWSHIP TRAINING PROGRAM IN VACCINOLOGYT32AI007524 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1997 to 2026
$6.4M
Genome-wide sieve analysis and immunological validation to identify targets of protective efficacy in field trials of a whole-organism malaria vaccineR01AI141900 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CARNEIRO DA SILVA, JOANA · 2019 to 2023
$3.9M
Variant surface antigens in cerebral malaria pathogenesisR01HL130750 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI FISHER, STEVEN A., PLOWE, CHRISTOPHER V. · 2015 to 2018
$2.1M
Malaria variant surface antigen expression and vulnerability to disease in Malian children with Hemoglobin C traitR01HL146377 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TRAVASSOS, MARK A · 2019 to 2023
$1.9M
Designing a diversity-covering multiantigen multi-strain vaccineK01HL140285 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI OUATTARA, AMED · 2019 to 2023
$712k
Host vulnerability and parasite genetics in the development of cerebral malariaR01AI099628 · NIAID · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · PI THERA, MAHAMADOU ALI · 2014 to 2018
$625k
Howard Hughes Medical InstituteNCI NIH HHS U54 CA272205NHLBI NIH HHS K01 HL140285NHLBI NIH HHS R01 HL130750NHLBI NIH HHS R01 HL146377NIAID NIH HHS R01 AI099628NIAID NIH HHS R01 AI141900NIAID NIH HHS T32 AI007524NIAID NIH HHS U19 AI110820
6 · The paper itself

Abstract

Plasmodium falciparum is the most virulent Plasmodium species, responsible for the life-threatening severe malaria syndromes of cerebral malaria and severe malarial anemia. In a Mali case-control study, we determined parasite gene expression in cerebral malaria, severe malarial anemia, and concurrent disease featuring both syndromes by comparing RNA-seq data from severe malaria cases to matched uncomplicated malaria controls with or without a history of cerebral malaria. While severe malarial anemia comparisons produced comparatively low levels of differential expression, the comparisons of cerebral malaria and concurrent disease yielded significant differential expression of multigene families (fikk, phist, and surf) implicated in processes that escalate disease severity, such as cytoadherence and erythrocytic remodeling. We probed custom microarrays featuring these antigens with acute and convalescent sera. Children with severe malaria developed antibody responses to subsets of these proteins following severe malaria infection, suggesting exposure to these antigens during illness and their potential as targets in the development of natural protective immunity against severe malaria. Our findings address knowledge gaps surrounding parasite gene expression in severe malarial anemia. Further, these results broaden the scope of multigene families implicated in severe malaria pathogenesis and underscore the utility of transcriptome-wide approaches for a comprehensive understanding of severe disease, particularly when developing therapeutics or vaccines.

Indexed as

Antibodies, ProtozoanMalaria, FalciparumMultigene FamilyPlasmodium falciparumProtozoan ProteinsAnemiaAntigens, ProtozoanCase-Control StudiesChildChild, PreschoolFemaleGene Expression ProfilingHumansInfantMalaria, CerebralMaleAntibodies, ProtozoanAntigens, ProtozoanProtozoan ProteinsCerebral malariaChildrenDifferential expressionGene ontologyMaliPlasmodium falciparumProtein microarrayRNA sequencingSevere malarial anemiaVaccine candidates

Identifiers

PMID41238081
PMCPMC12854251

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.