ArticleImmunity2026
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry.
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Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
7 citing papers in PubMed.
- Article
- SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells.EMBO reports · 2026Article
- Enhancer hubs govern chromatin topology and Th17 cell identity.bioRxiv : the preprint server for biology · 2026Article
- Tumor-Infiltrating Immune Cells Are More Abundant in Lung Metastases From Colorectal Cancer Than in Paired Primary Tumors and Their Prognostic Value Depends on Adjuvant Chemotherapy.Cancer medicine · 2026Article
- Review
- Thirty years in, regulatory T cells are ready for medicine.Frontiers in immunology · 2026Review
- Tissue repair in the central nervous system: the epigenetic programming of regulatory T cells.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
30 authors.
Jennifer M UmhoeferGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: jenny@sitetx.com.
Maya M ArceGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Sivakanthan KasinathanGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sean WhalenGladstone Institute of Data Science and Biotechnology, San Francisco, CA 94158, USA.
Rama DajaniGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.
Sanjana SubramanyaGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.
Laine GoudyGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Julia A BelkCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA.
Royce ZhouGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Molecular Medicine Program, Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Minh T N PhamDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wenxi ZhangDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Rosmely HernandezGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.
Carinna TranGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.
Nikhita KirthivasanGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Jacob W FreimerGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Cody T MoweryGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Vinh NguyenGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Mineto OtaGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Benjamin G GowenInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Dimitre R SimeonovDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Gemma L CurieInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Zhongmei LiGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Andy Y ChenDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jacob E CornDepartment of Biology, Institute of Molecular Health Sciences, ETH Zürich, 8093 Zürich, Switzerland.
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Qizhi TangDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Luke A GilbertArc Institute, Palo Alto, CA 94304, USA; Department of Urology, University of California, San Francisco, San Francisco, CA 94143, USA.
Ansuman T SatpathyGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA.
Katherine S PollardGladstone Institute of Data Science and Biotechnology, San Francisco, CA 94158, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA; Chan Zuckerberg Biohub SF, San Francisco, CA 94158, USA.
Alexander MarsonGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: alex.marson@gladstone.ucsf.edu.
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8MDIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3MSpatial multiomic mapping of gene function with CRISPRoffUM1HG012660 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Luke Gilbert · 2022 to 2026
$8.2MIntegration of genetic association mapping and functional data to elucidate genetic mechanisms of diseaseR01HG008140 · NHGRI · STANFORD UNIVERSITY · PI JONATHAN K PRITCHARD · 2016 to 2026
$7.3MTraining Program in Adult and Pediatric RheumatologyT32AR050942 · NIAMS · STANFORD UNIVERSITY · PI LEWIS, DAVID BRAM, ROBINSON, WILLIAM H · 2005 to 2025
$6.6MRestorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5MA GENETIC INTERACTION MAP OF THE HUMAN NUCLEUSDP2CA239597 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GILBERT, LUKE · 2018 to 2018
$2.4MIllumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583kBD FACSAria II Flow CytometerS10RR028962 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI CAVROIS, MARIELLE · 2011 to 2011
$544kFunctional mapping of ex-regulatory T cell phenotypic diversityF30AI157167 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOWERY, CODY · 2021 to 2023
$130kNCI NIH HHS DP2 CA239597NCRR NIH HHS S10 RR028962NHGRI NIH HHS R01 HG008140NHGRI NIH HHS UM1 HG012660NIAID NIH HHS F30 AI157167NIAMS NIH HHS T32 AR050942NIDDK NIH HHS P30 DK063720NIDDK NIH HHS T32 DK007418NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM136547NIH HHS S10 OD028511
Abstract
FOXP3 is a lineage-defining transcription factor (TF) for immune-suppressive regulatory T cells (Treg cells). Although mice exclusively express FOXP3 in Treg cells, stimulated conventional CD4
Indexed as
Forkhead Transcription FactorsGene Expression RegulationRegulatory Elements, TranscriptionalRegulatory Sequences, Nucleic AcidT-Lymphocytes, RegulatoryTranscription FactorsAnimalsHumansMiceMice, Inbred C57BLForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseTranscription FactorsCRISPRenhancersepigeneticsFOXP3gene regulationregulatory T cellsT cellstranscription factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.