Evidence map›Paper›PMID 41237753›Full record

ArticleJournal of inorganic biochemistry2026

Methionine coordination to the heme iron and its displacement by nitric oxide in the CcoP subunit of Pseudomonas aeruginosa cytochrome cbb

Jia Yang, Fangfang Zhong, Therese Albert, Pierre Moënne-Loccoz, Ekaterina V Pletneva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jia YangDepartment of Chemistry, Dartmouth College, Hanover, NH 03755, United States.
Fangfang ZhongDepartment of Chemistry, Dartmouth College, Hanover, NH 03755, United States.
Therese AlbertDepartment of Chemical Physiology and Biochemistry, School of Medicine, Oregon Health & Science University, Portland, OR 97239, United States.
Pierre Moënne-LoccozDepartment of Chemical Physiology and Biochemistry, School of Medicine, Oregon Health & Science University, Portland, OR 97239, United States.
Ekaterina V PletnevaDepartment of Chemistry, Dartmouth College, Hanover, NH 03755, United States. Electronic address: ekaterina.pletneva@dartmouth.edu.

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

Ligand substitution is common in signaling mechanisms of heme proteins. Methionine at the heme iron can get displaced by both endogenous and exogeneous ligands, including NO. The latter is particularly relevant in low-O

Indexed as

Bacterial ProteinsElectron Transport Complex IVHemeIronMethionineNitric OxidePseudomonas aeruginosaBacterial Proteinscbb3 oxidaseElectron Transport Complex IVHemeIronMethionineNitric OxideCytochromeElectron transferHeme sensorsLigand substitution

Identifiers

PMID41237753
PMCPMC12834235

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.