Evidence map›Paper›PMID 41237591›Full record

ArticleInternational dental journal2026

Mendelian Randomization and ScTranscriptomics Reveal a Lipid Low Malignant Cells Driving Immunosuppression and Matrix Remodeling in Oral squamous cell carcinoma.

Kaixin Su, Jia Mi, Rifu Wang, Jian Zhou, Fei Yan, Ousheng Liu

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Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kaixin SuHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China.
Jia MiHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China.
Rifu WangHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China.
Jian ZhouSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, China; Department of VIP Dental Service, School of Stomatology, Capital Medical University, Beijing, China; Laboratory for Oral and General Health Integration and Translation, Beijing Tiantan Hospital, Capital Medical University, Beijing China.
Fei YanHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China. Electronic address: yfann_2004@163.com.
Ousheng LiuHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China. Electronic address: liuousheng@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

aimsOral squamous cell carcinoma (OSCC) represent a frequently occurring malignant neoplasm in the head and neck region, characterized by a high rate and poor prognosis. Current research on lipid metabolism predominantly centers on inducing lipotoxicity through the disruption of lipid homeostasis and the reduction of signaling lipid availability, which has been demonstrated to inhibit the progression of OSCC.

methodsTo figure out the risk with weak prognosis, we conducted a dual validation with a multi-omics approach combining Mendelian randomization (MR) and single-cell RNA sequencing(scRNA-seq).

resultsThis strategy enabled us to conclude that the Lipid_Low cell population, a subpopulation of malignant cells with low correlation with glycerophospholipid (GP) metabolism, was associated with poor prognostic properties of OSCC patients. This characteristic was accompanied by stronger migratory ability, proliferative activity, and possible immune escape characteristics. The Lipid_Low subpopulation may represent a class of clinically significant high-risk cellular states.

conclusionIn terms of transcriptional features, Lipid-associated Low-malignancy cells may be significantly correlated with poor patient prognosis, thereby providing a foundation for future research into targeted therapeutic strategies. CLINICAL RELEVANCE: These findings also suggest that lipid metabolism could serve as a potential biomarker for assessing the clinical prognosis of patients with OSCC.

Indexed as

Carcinoma, Squamous CellLipid MetabolismMendelian Randomization AnalysisMouth NeoplasmsSquamous Cell Carcinoma of Head and NeckHumansPrognosisSingle-Cell AnalysisMR analysisOSCCplasma lipid speciesprognosisscRNA-seq

Identifiers

PMID41237591
PMCPMC12663504

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