Evidence map›Paper›PMID 41237590›Full record

ArticleInternational dental journal2026

Multifunctional Thermal-responsive Bioglue Targeted at Suppurative Infection in Oral Cavity.

Changjie Sun, Yifei Zhang, Yukun Mei, Yuwei Zhang, Jizhou Wang, Yuxin Niu, Yuting Wang, Jingning Gou, Luming Wang, Lin Niu and 1 more

Abstract read
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In one paragraph

Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Changjie SunKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Yifei ZhangDepartment of Stomatology, Tongxiang Hospital of Traditional Chinese Medicine, Tongxiang, Zhejiang Province, China.
Yukun MeiKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Yuwei ZhangDepartment of Engineering, The Chinese University of Hong Kong, NT, Hong Kong SAR, China.
Jizhou WangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Yuxin NiuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Yuting WangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Jingning GouKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Luming WangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Lin NiuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Electronic address: niulin@xjtu.edu.cn.
Shaojie DongKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Electronic address: dongshaojie@xjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to develop a novel thermal-responsive bioglue against suppurative infection in the oral cavity, to overcome the current conventional therapeutic strategies, encompassing localised irrigation and systemic pharmacotherapy, which are constrained by transient therapeutic duration, suboptimal drug bioavailability, delayed therapeutic onset, and adverse systemic effects. MATERIALS AND

methodsMultifunctional bio-adhesive platform comprising tannic acid-iron ion chelate (TA-Fe) with thermal-responsive poly (N-isopropylacrylamide) hydrogel (PPP) (TA-Fe@PPP) was designed for spatially confined photothermal therapeutic intervention with the use of a near-infrared (NIR) laser. Furthermore, comprehensive performance, including gel transformation, degradation behaviour, adhesive and photothermal properties, drug release, and antibacterial activity in vitro and in vivo, was assessed.

resultsThe TA-Fe@PPP system showed porous morphology, ideal adhesive performance, and thermal-responsive behaviour. Favourable biocompatibility and antimicrobial and soft tissue regeneration ability were also confirmed both in vitro and in vivo.

conclusionsTA-Fe@PPP's sustained efficacy with minimised off-target effects holds significant localised therapeutic potential, highlighting a long-lasting in situ platform for oral suppurative infection. CLINICAL SIGNIFICANCE: TA-Fe@PPP can be utilized as a durable in situ platform to treat oral suppurative infections as a versatile carrier system. This novel system addresses critical needs across multiple therapeutic scenarios in clinical practice.

Indexed as

Anti-Bacterial AgentsHydrogelsMouthAcrylic ResinsAnimalsDrug LiberationMiceSuppurationTanninsAcrylic ResinsAnti-Bacterial AgentsHydrogelspoly-N-isopropylacrylamideTanninsBiogluePhotothermalSuppurative infectionTannic acidThermal-responsive

Identifiers

PMID41237590
PMCPMC12663493

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.