Evidence map›Paper›PMID 41237333›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Obesity-Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis.

Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang and 1 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haohui WangDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.ORCID https://orcid.org/0009-0001-9030-0968
Chong YangDepartment of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Dayuan LuoDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Pingting LiuDepartment of Health Management Center, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, 410008, China.
Zhen ZengDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Weilin PengDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Dongzi PengDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Hao SuDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Xiaoxiong XiaoDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Haiqin WangDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Xin JinDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.ORCID https://orcid.org/0000-0001-6461-6005

Funding

National Natural Science Youth Foundation of China 82 203 838Natural Science Foundation of Hunan Province 2024JJ5481Sichuan Science and Technology Programs 2024NSFSC0748
6 · The paper itself

Abstract

Obesity has been identified as an independent risk factor for gastroesophageal reflux disease (GERD) and esophageal adenocarcinoma (EAC). Oxidative stress and inflammation driven by chronic GERD are the main causes of the tumorigenesis of EAC, but the underlying mechanism remains elusive. Here, the inflammation-upregulated E3 ligase, tripartite motif 15 (TRIM15), is identified as a key driver of obesity-associated EAC. TRIM15 promotes the degradation of YY2 is demonstrated through the ubiquitin-proteasome system, which in turn dysregulates lipid metabolism and enhances the proliferation of EAC cells. Furthermore, YY2 transcriptionally is shown that increases FOXRED1 expression. FOXRED1 is subsequently identified as an essential effector for the TRIM15-induced dysregulation of lipid and energy metabolism in EAC cells. Thus, a novel obesity-associated TRIM15/YY2/FOXRED1 axis is identified that contributes to the proliferation of EAC. Given that lipid metabolism regulates ferroptosis by controlling cellular processes associated with phospholipid peroxidation. The TRIM15/YY2/FOXRED1 axis demonstrates that it modulates SLC3A2 expression via the mTOR/c-MYC pathway, thereby regulating GPX4 levels to influence EAC sensitivity to ferroptosis-inducing compounds and proposing a therapeutic strategy for EAC.

Indexed as

AdenocarcinomaEsophageal NeoplasmsObesityTripartite Motif ProteinsUbiquitin-Protein LigasesCell Line, TumorCell ProliferationHumansLipid MetabolismTripartite Motif ProteinsUbiquitin-Protein Ligasesesophageal adenocarcinomaferroptosislipid metabolismobesityTRIM15

Identifiers

PMID41237333
PMCPMC12822407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.