Evidence map›Paper›PMID 41237252›Full record

ArticleScience advances2025

Serine tRNAs compete to regulate the mRNA translation of serine-sensitive codons.

Veronica Costiniti, Wyatt C Tran, Nandhini Rajesh Babu, Evgeny Kanshin, Beatrix Ueberheide, Alec C Kimmelman, Robert S Banh

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Veronica CostinitiDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-8472-7797
Wyatt C TranDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.ORCID 0009-0002-6162-6261
Nandhini Rajesh BabuDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.ORCID 0009-0008-7676-8805
Evgeny KanshinDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Beatrix UeberheideDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-2512-0204
Alec C KimmelmanLaura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York University, New York, NY 10016, USA.ORCID 0009-0002-9465-8411
Robert S BanhDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-1959-4622

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
The RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2006 to 2025
$41.7M
Identifying Metabolic Dependencies of Pancreatic CancersR35CA232124 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIMMELMAN, ALEC · 2018 to 2024
$6.5M
Targeting the autophagy-lysosome system to block pancreatic cancerR01CA251726 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERERA, RUSHIKA MIRIAM · 2021 to 2025
$1.8M
Elucidating The Adaptive Role Of Serine Codons During Pancreatic Tumorigenesis - Diversity SupplementR37CA289040 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Robert Singhung Banh · 2024 to 2026
$1.8M
NCI NIH HHS P01CA117969NCI NIH HHS P30CA016087NCI NIH HHS R01 CA251726NCI NIH HHS R35 CA232124NCI NIH HHS R37 CA289040
6 · The paper itself

Abstract

Differential mRNA translation efficiency (mTE) of codons is important in regulating protein synthesis and cellular states and can change in response to amino acid availability. While the mTE of codons is canonically associated with their corresponding transfer RNA (tRNA) isoacceptors, its regulation by amino acids in mammalian cells remains unexplored. We found that ELAC2, a 3' tRNA maturation endonuclease, decreases the mTE of UC[C/U] serine (Ser) codons in response to Ser limitation. Ablation of ELAC2 restored UC[C/U] mTE but reduced the mTE of AG[U/C] Ser codons. Among the tRNA

Indexed as

CodonProtein BiosynthesisRNA, MessengerRNA, Transfer, SerSerineHEK293 CellsHumansCodonRNA, MessengerRNA, Transfer, SerSerine

Identifiers

PMID41237252
PMCPMC12617527

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.