Evidence map›Paper›PMID 41237223›Full record

ArticleScience advances2025

Structural and epistatic regulatory variants cause hallmark white spotting in cattle.

Swati Jivanji, Emma Wilkinson, Lijing Tang, Kathryn M Tiplady, Anna Yeates, Chad Harland, Charlotte Gray, Christine Couldrey, Gemma Worth, Isabelle Gamache and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Swati JivanjiLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.ORCID 0000-0001-6824-1730
Emma WilkinsonSchool of Biomedical and Life Sciences, Lancaster University, Lancaster, UK.ORCID 0000-0002-7261-3338
Lijing TangUnit of Animal Genomics, GIGA and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.ORCID 0000-0001-9742-769X
Kathryn M TipladyLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.ORCID 0000-0002-3307-9208
Anna YeatesLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.ORCID 0009-0000-8755-883X
Chad HarlandLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.ORCID 0000-0002-6268-0107
Charlotte GrayLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.
Christine CouldreyLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.
Gemma WorthLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.ORCID 0009-0006-7550-2904
Isabelle GamacheMcGill Integrated Core of Animal Modeling, McGill University, Montreal, Canada.
Jade DesjardinsMcGill Integrated Core of Animal Modeling, McGill University, Montreal, Canada.ORCID 0009-0007-7320-5815
John A A TabaresMcGill Integrated Core of Animal Modeling, McGill University, Montreal, Canada.ORCID 0009-0000-7684-7329
Nobuko YamanakaMcGill Integrated Core of Animal Modeling, McGill University, Montreal, Canada.
Lorna McNaughtonLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.ORCID 0000-0001-6194-8063
Louise BrennanInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID 0000-0003-0324-2665
Marie-Pier CloutierMcGill Integrated Core of Animal Modeling, McGill University, Montreal, Canada.ORCID 0009-0009-8667-3997
Mitra CowanMcGill Integrated Core of Animal Modeling, McGill University, Montreal, Canada.ORCID 0000-0003-1327-5233
Renae EllisonLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.
Tony FransenLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.
Tracey MonehanLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.ORCID 0009-0003-5887-769X
Richard J SpelmanLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.
Russell G SnellSchool of Biological Sciences, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-8166-4014
Carole CharlierUnit of Animal Genomics, GIGA and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.ORCID 0000-0002-9694-094X
Yojiro YamanakaMcGill Integrated Core of Animal Modeling, McGill University, Montreal, Canada.ORCID 0000-0003-1483-8691
Dorian GarrickAL Rae Centre for Genetics and Breeding, School of Agriculture and Environment, Massey University, Hamilton, New Zealand.ORCID 0000-0001-8640-5372
Richard MortSchool of Biomedical and Life Sciences, Lancaster University, Lancaster, UK.ORCID 0000-0002-3566-8217
Mathew D LittlejohnLivestock Improvement Corporation, Newstead, Hamilton, New Zealand.ORCID 0000-0001-9044-047X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite being one of the most iconic and immediately recognizable traits in domestic cattle, the variants underpinning the white-spotted coat pattern of Holstein-Friesian and related breeds remain uncharacterized. Here, we report two variants modulating these effects, comprising intronic and long-distance-acting regulatory variants of the

Indexed as

CattleEpistasis, GeneticGenomic Structural VariationPolymorphism, Single NucleotideSkin PigmentationAllelesAnimalsFemaleIntronsMaleMiceMice, TransgenicMicrophthalmia-Associated Transcription FactorModels, AnimalPhenotypeProto-Oncogene Proteins c-kitMicrophthalmia-Associated Transcription FactorMitf protein, mouseProto-Oncogene Proteins c-kit

Identifiers

PMID41237223
PMCPMC12617462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.