Observational studyPloS one2025
The mediating role of blood metabolites in the association between myocardial infarction and cancer risk: An observational and mendelian randomization analysis.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Causal effects between blood metabolites and myocardial infarction: A 2-sample Mendelian randomization study.Medicine · 2026Article
- Cardiometabolic comorbidities and prostate cancer risk: evidence from the prostate, lung, colorectal, and ovarian cancer screening trial.Frontiers in oncology · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyocardial infarction (MI) and cancer are major global public health challenges. Research indicates that they share common risk factors and that physiological changes following MI may affect cancer incidence and progression. However, evidence defining the independent relationship between these conditions is still limited.
methodsWe analyzed data from the National Health and Nutrition Examination Survey (NHANES) (2011-2018) using multivariable weighted logistic regression to examine the association between myocardial infarction (MI) and cancer. Additionally, we utilized genome-wide association study (GWAS) summary statistics and conducted Mendelian randomization (MR) to assess potential causal relationships and explore underlying mechanisms. Sensitivity analyses were performed to ensure the robustness of our findings.
resultsA total of 20,859 participants were included in our observational study using NHANES data. Multivariable weighted logistic regression revealed no direct association between MI and cancer (OR=1.161, 95% CI [0.895-1.507], P = 0.261). Interestingly, MR analysis indicated that MI occurrence was associated with a reduced incidence of cancer (OR=0.9497, 95% CI [0.9223-0.9778], P = 0.0005). Furthermore, two-stage MR results suggested this reduction might be mediated by increased blood levels of metabolites that inhibit cancer development, such as dihomo-linoleate (20:2n6) (beta = -0.0050, 95% CI [-0.0027-0.0004], P < 0.0001), alpha-tocopherol (beta = -0.0042, 95% CI [-0.0060-0.0025], P < 0.0001), inosine (beta = -0.0015, 95% CI [-0.0027-0.0004], P = 0.0084), and methyl glucopyranoside (alpha + beta) levels (beta = -0.0006, 95% CI [-0.0010-0.0003], P = 0.0008).
conclusionOur integrative analysis suggests that myocardial infarction may be associated with a reduced cancer incidence through potential alterations in blood metabolite profiles, including dihomo-γ-linolenic acid, alpha-tocopherol, and inosine. These findings provide preliminary evidence that warrants further large-scale studies to validate the observed associations and to elucidate the underlying mechanisms.
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