Evidence map›Paper›PMID 41237174›Full record

ArticleChemistry & biodiversity2026

Discovery of Scalarane Sesterterpenoids From the Mollusk Glossodoris hikuerensis Exhibiting Anticancer Effects Against Drug-resistant Lung Cancer Cells.

Xiao Xiao, Li-Ting Zhang, Chen-Lu Du, Chuan Zhang, Yi-Ming Lu, Ming-Zhi Su, Song-Wei Li, Yue-Wei Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiao XiaoSchool of Medicine, Shanghai University, Shanghai, China.
Li-Ting ZhangShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, China.
Chen-Lu DuSchool of Medicine, Shanghai University, Shanghai, China.
Chuan ZhangSchool of Medicine, Shanghai University, Shanghai, China.
Yi-Ming LuSchool of Medicine, Shanghai University, Shanghai, China.
Ming-Zhi SuShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, China.
Song-Wei LiSchool of Medicine, Shanghai University, Shanghai, China.
Yue-Wei GuoSchool of Medicine, Shanghai University, Shanghai, China.ORCID https://orcid.org/0000-0003-0413-2070

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new scalarane-type sesterterpene (1), along with four known related compounds (2-5), was isolated from the nudibranch mollusk Glossodoris hikuerensis. Compound 6 was also obtained from 4 by chemical conversion. Their structures were established by extensive spectroscopic analysis, chemical conversion, and by the comparison of their spectroscopic data with those reported in the literature. In bioassay, compound 1 inhibited the proliferation of human leukemia U937 cells with a half-maximal inhibitory concentration (IC

Indexed as

Antineoplastic AgentsDrug DiscoveryDrug Resistance, NeoplasmLung NeoplasmsMolluscaSesterterpenesAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorErbB ReceptorsHumansMembrane Potential, MitochondrialAntineoplastic AgentsErbB ReceptorsPhosphatidylinositol 3-KinasesSesterterpenesanticancer activitydrug‐resistant cancer cellGlossodoris hikuerensisNudibranch mollusksesterterpenes

Identifiers

PMID41237174
PMCPMC13421863

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.