Evidence map›Paper›PMID 41237081›Full record

ArticleRespiration; international review of thoracic diseases2026

Prevalence and Environmental Correlates of Small Airways Dysfunction in a Rural Swiss Cohort.

Marco Fiori, Dragana Radovanovic, Alessio Casutt, Brice Touilloux, Christophe Von Garnier, Andreas W Schoenenberger, Augusto Gallino, Paolo M Suter, Franco Muggli, Adam Ogna

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Article in Respiration; international review of thoracic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Small airways dysfunction: associated factors, clinical aspects and new perspectives.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marco FioriInternal Medicine Division, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Dragana RadovanovicFaculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland.
Alessio CasuttFaculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland.
Brice TouillouxDivision of Pulmonology, Department of Medicine, Lausanne University Hospital (CHUV), and University of Lausanne (UNIL), Lausanne, Switzerland.
Christophe Von GarnierDivision of Pulmonology, Department of Medicine, Lausanne University Hospital (CHUV), and University of Lausanne (UNIL), Lausanne, Switzerland.
Andreas W SchoenenbergerDepartment of Internal Medicine, Kantonsspital Münsterlingen, Münsterlingen, Switzerland.
Augusto GallinoInternal Medicine Division, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Paolo M SuterDepartment of Endocrinology, Diabetology and Clinical Nutrition, Universitätsspital Zürich, Zurich, Switzerland.
Franco MuggliFaculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland.
Adam OgnaInternal Medicine Division, Ente Ospedaliero Cantonale, Bellinzona, Switzerland, adam.ogna@usi.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: Small airways dysfunction (SAD) is increasingly recognized as an early marker of respiratory disease. Recent cohort studies have reported wide variability in SAD prevalence across countries, suggesting a possible role of air pollution as a contributing factor. This study aimed to assess SAD prevalence in a general population from rural Switzerland, compare it to existing cohorts, and identify associated factors.

methodsWe analysed data from the Swiss Longitudinal Cohort Study (SWICOS), conducted in two neighbouring rural villages in Southern Switzerland (Cama and Lostallo). All participants underwent spirometry, with SAD defined as a maximal mid expiratory flow below the lower limit of normal. Air pollution data were obtained from official monitoring stations located within 10 km of the study site.

resultsThe study included 423 participants (mean age 50.4 ± 16.3 years; 43.7% male). SAD prevalence was 2.60% (95% CI: 1.46-4.60), significantly associated with active smoking but not with age, BMI, or respiratory symptoms. Exposure to particulate matter was lower than in other international cohorts.

conclusionIn this rural Swiss population study, SAD prevalence was slightly lower than in the Swiss urban cohort and markedly lower than in other recent studies, which involved populations exposed to higher levels of air pollution. These findings support growing evidence that air pollution exposure may contribute to early small airways impairment. </p>.

Indexed as

Air PollutionEnvironmental ExposureAdultAgedCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedParticulate MatterPrevalenceRural PopulationSmokingSpirometrySwitzerlandParticulate MatterAir pollutionParticulate matterRuralSmall airwaysSmall airways dysfunction

Identifiers

PMID41237081
PMCPMC12716844

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.