ArticleObesity facts2026
Early-Onset of Obesity Model: Impact of Early-Onset Obesity on Comorbidity Risk and Life Expectancy.
Article in Obesity facts, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Long-Term Cardiometabolic Outcomes in Children With Metabolically Healthy and Unhealthy Obesity.JAMA pediatrics · 2026Article
- "It's the biggest not one-size-fits-all service I've ever worked in": the realities of delivering a 'Complications of Excess Weight' service for children and young people in England from a multidisciplinary team perspective.BMC health services research · 2026Article
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Authors and funding
16 authors.
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No grant is acknowledged in the PubMed record.
Abstract
<p>Introduction: Early-onset obesity increases the risk of developing comorbidities and decreases life expectancy with many variables such as age of onset, severity, and duration of obesity each having an individual influence. Here, we present findings from a model that aims to assess the impact of early-onset obesity.
methodsThe Early-Onset Obesity Model (EOObesity Model) was built by integrating data from clinical studies with demographic information. It categorizes information into four primary groups: prevalence, morbidity risk, mortality risk, and impact of obesity duration. Type 2 diabetes, cardiovascular events (fatal and nonfatal events, cardiovascular disease, and coronary heart disease), metabolic dysfunction-associated steatotic liver disease, asthma, obstructive sleep apnea, and cancer were evaluated over a range of age and body mass index (BMI) z-scores.
resultsThe EOObesity Model provides a systematic approach for estimating the impact of early-onset obesity on risk of comorbidities and on life expectancy by considering individual patient weight trajectories. We test different scenarios to illustrate the potential impact of age of onset and severity of obesity on the risk of various comorbidities, on life expectancy, and on disability-adjusted life years. The model indicates that severe early-onset obesity has a high impact on life expectancy with, for example, up to 42 years of life lost if a patient has a BMI z-score of 4 by the age of 4 years. DISCUSSION: The model and these scenarios underscore the predicted substantially detrimental effects of early-onset and prolonged obesity on life expectancy, and the increased risks of obesity-related comorbidities. They suggest that morbidity and mortality risks increase with obesity duration and severity in a nonlinear manner, thereby supporting the view that early weight-loss intervention and obesity prevention strategies may reduce long-term health risks substantially. </p>.
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