Evidence map›Paper›PMID 41236814›Full record

ArticleeLife2025

Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein.

Yasuhiro Shinkai, Yunjie Ding, Toru Matsui, George Devitt, Masahiro Akiyama, Tang-Long Shen, Motohiro Nishida, Tomoaki Ida, Takaaki Akaike, Sumeet Mahajan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yasuhiro ShinkaiEnvironmental Biology Laboratory, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.ORCID 0000-0003-1772-5342
Yunjie DingDoctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Toru MatsuiDepartment of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Japan.
George DevittCentre for Biological Sciences, University of Southampton, Highfield Campus, Southampton, United Kingdom.
Masahiro AkiyamaEnvironmental Biology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Tang-Long ShenDepartment of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan.
Motohiro NishidaGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-2587-5458
Tomoaki IdaDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takaaki AkaikeDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID 0000-0002-0623-1710
Sumeet MahajanSchool of Chemistry and the Institute for Life Sciences, University of Southampton, Highfield Campus, Southampton, United Kingdom.
Jon M FukutoDepartment of Chemistry, Johns Hopkins University, Baltimore, United States.
Yasuteru ShigetaCenter for Computational Sciences, University of Tsukuba, Tsukuba, Japan.
Yoshito KumagaiEnvironmental Biology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.ORCID 0000-0003-4523-8234

Funding

Japan Society for the Promotion of Science #18H05293Japan Society for the Promotion of Science #20H04340Japan Society for the Promotion of Science #21KK0207Japan Society for the Promotion of Science #22H04799Japan Society for the Promotion of Science #22H05555
6 · The paper itself

Abstract

Cysteine-bound sulfane sulfur atoms in proteins have received much attention as key factors in cellular redox homeostasis. However, the role of sulfane sulfur in zinc regulation has been underinvestigated. In this study, we identified growth inhibitory factor (GIF)/metallothionein-3 (MT-3) as a sulfane sulfur-binding protein from mouse brain. We also report here that cysteine-bound sulfane sulfur atoms serve as ligands to hold and release zinc ions in GIF/MT-3 with an unexpected C-S-S-Zn structure. Oxidation of such a zinc/persulfide cluster in Zn

Indexed as

Metallothionein 3SulfurAnimalsBrainCysteineMiceModels, MolecularOxidation-ReductionProtein BindingSulfidesZincCysteineMetallothionein 3persulfidesSulfidesSulfurZincbiochemistrychemical biologymetallothionein-3mouseredoxsulfane sulfurzinc

Identifiers

PMID41236814
PMCPMC12618007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.