ArticleeLife2025
Relationship between cognitive abilities and mental health as represented by cognitive abilities at the neural and genetic levels of analysis.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
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Abstract
Cognitive abilities are closely tied to mental health from early childhood. This study explores how neurobiological units of analysis of cognitive abilities-multimodal neuroimaging and polygenic scores (PGS)-represent this connection. Using data from over 11,000 children (ages 9-10) in the Adolescent Brain Cognitive Development (ABCD) Study, we applied multivariate models to predict cognitive abilities from mental health, neuroimaging, PGS, and environmental factors. Neuroimaging included 45 MRI-derived features (e.g. task/resting-state fMRI, structural MRI, diffusion imaging). Environmental factors encompassed socio-demographics (e.g. parental income/education), lifestyle (e.g. sleep, extracurricular activities), and developmental adverse events (e.g. parental use of alcohol/tobacco, pregnancy complications). Cognitive abilities were predicted by mental health (r = 0.36), neuroimaging (r = 0.54), PGS (r = 0.25), and environmental factors (r = 0.49). Commonality analyses showed that neuroimaging (66%) and PGS (21%) explained most of the cognitive-mental health link. Environmental factors accounted for 63% of the cognitive-mental health link, with neuroimaging and PGS explaining 58% and 21% of this environmental contribution, respectively. These patterns remained consistent over two years. Findings highlight the importance of neurobiological units of analysis for cognitive abilities in understanding the cognitive-mental health connection and its overlap with environmental factors.
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