Evidence map›Paper›PMID 41236717›Full record

ArticleFuture science OA2025

Lactate levels and heart failure: causal insights from Mendelian randomization and multi-cohort integrated analyses.

Shijiu Jiang, Shuai Zhou, Runtian Dong, Yankai Xu, Haiying Hu, Kejian Liu

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Article in Future science OA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shijiu JiangDepartment of Cardiology, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Shuai ZhouDepartment of Cardiology, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Runtian DongDepartment of Cardiology, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Yankai XuDepartment of Cardiology, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Haiying HuDepartment of Nephrology, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Kejian LiuDepartment of Cardiology, The First Affiliated Hospital of Shihezi University, Shihezi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the causal link between genetic predisposition for elevated lactate levels and heart failure (HF) via Mendelian randomization (MR), and investigate lactate-related genetic mechanisms and mediating pathways.

methodsLactate and HF summary data were from genome-wide association studies (GWAS). MR analyses used inverse variance weighting (IVW) as the main method; cardiac imaging trait MR focused on UK Biobank data. Mediation analysis examined CD20

resultsMR showed that genetically predicted elevated lactate causally increased HF risk independent of hypoperfusion (reverse causality excluded) and reduced left ventricular ejection fraction (LVEF), implying a cardiac function-impairment pathway. NUP50, a key lactate-related gene, positively associated with HF. Its HF effect was partially mediated by CD20

conclusionElevated lactate may increase HF risk via impaired cardiac function. NUP50 and other lactate-related genes may regulate HF risk (NUP50 partially via CD20

Indexed as

heart failureLactate levelsLVEFmediation analysismendelian randomizationNUP50 CD20+ memory B cells

Identifiers

PMID41236717
PMCPMC12622332

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