ArticleBiological trace element research2026
Comparative Study of Nicotine Content in Moldavian Tobacco by UV-Vis Spectrophotometry and UHPLC and their Mineral Composition by ICP-OES.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Heavy Metal Contamination and Health Risk Assessment of Roll-Your-Own Tobacco in Türkiye.Biological trace element research · 2026Article
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8 authors.
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Abstract
Tobacco is one of the oldest cultures known to mankind for more than 5000 years. Despite the proven harm by smoking, the number of smokers in Moldova is growing, making the quality control of tobacco products an important task. This study focused on the quantification of nicotine and the determination of the mineral composition in autochthonous Moldavian tobacco selections. Ultraviolet-visible (UV-Vis) spectroscopy and ultrahigh performance liquid chromatography (UHPLC) were applied for quantification of nicotine in ten tobacco varieties (Molovata, Trapezond 209, Doina 210, Moldavschi 237, Virginia 263, Moldavschi 272, Burley 320, Virginia 401, Moldavschi 456, Jubileu M) and Nicotiana rustica L. species of Moldavian origin. The nicotine content determined by UV-Vis analysis ranged from 1.24% to 2.74%, while UHPLC analysis yielded a range of 0.97% to 2.16% and the difference is due to the higher selectivity and accuracy of the UHPLC method. A total of 14 chemical elements, Al, S, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Sr, Cd, Ba and Hg, were identified in tobacco varieties by inductively coupled plasma-optical emission spectrometry. The mean elements content in tobacco leaves samples was the following: Al (1390 ± 795 mg/kg), S (3043 ± 749 mg/kg), V (1.9 ± 1.1 mg/kg), Cr (2.5 ± 1.3 mg/kg), Mn (126 ± 21 mg/kg), Fe (1077 ± 579 mg/kg), Co (0.39 ± 0.19 mg/kg), Ni (2.4 ± 0.9 mg/kg), Cu (3.9 ± 1.5 mg/kg), Zn (13.8 ± 3.3 mg/kg), Sr (164 ± 17 mg/kg), Cd (1.4 ± 0.3 mg/kg), Ba (62 ± 12 mg/kg) and Hg (0.04 ± 0.005 mg/kg). Principal components analysis, applied for element grouping, revealed two groups of elements, which can be associated with elements uptake by plants from soil, agricultural practices, fuel combustion, and vehicles and road dust.
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