Evidence map›Paper›PMID 41236682›Full record

ArticleNeurochemical research2025

Investigation of the Effects of Lacticaseibacillus rhamnosus GG Administration on Penicillin-Induced Epileptiform Activity in Rats.

Murat Tekbas, Serif Demir, Ersin Beyazcicek, Ozge Beyazcicek, Ali Gok

Abstract read
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In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Murat TekbasDepartment of Physiology, Faculty of Medicine, Duzce University, Duzce, Turkey.
Serif DemirDepartment of Physiology, Faculty of Medicine, Duzce University, Duzce, Turkey.
Ersin BeyazcicekDepartment of Physiology, Faculty of Medicine, Duzce University, Duzce, Turkey. beyazcicek13@gmail.com.
Ozge BeyazcicekDepartment of Physiology, Faculty of Medicine, Duzce University, Duzce, Turkey.
Ali GokDepartment of Physiology, Faculty of Medicine, Duzce University, Duzce, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excitatory/inhibitory balance, oxidative and antioxidative regulatory systems play a role in the pathophysiology of epilepsy. In addition, intestinal dysbiosis is also involved in the pathophysiology of epilepsy. The aim of this study was to investigate the effects of Lacticaseibacillus rhamnosus GG (L. rhamnosus or LBR) on epileptic seizures and gamma aminobutyric acid (GABA), malondealdehyde (MDA), superoxide dismutase (SOD, glutathione peroxidase (GPx) and catalase (CAT) levels in serum and brain tissue in a penicillin-induced acute seizure model in rats. The study included 70 adult Wistar albino rats, which were divided into 10 groups: Control(CONT), Penicillin (PEN), only LBR-4 (OLBR-4), Diazepam-4 + Penicillin (DZM-4 + PEN), LBR-4 + Penicillin (LBR-4 + PEN), LBR + Diazepam-4 + Penicillin (LBR-DZM-4 + PEN), only LBR-10 (OLBR-10), Diazepam-10 + Penicillin (DZM-10 + PEN), LBR-10 + Penicillin (LBR-10 + PEN), and LBR + Diazepam-10 + Penicillin (LBR-DZM-10 + PEN). 1 × 10

Indexed as

Lacticaseibacillus rhamnosusProbioticsSeizuresAnimalsBrain-Gut AxisElectrocorticographygamma-Aminobutyric AcidMaleOxidantsPenicillinsRatsRats, Wistargamma-Aminobutyric AcidOxidantsPenicillinsAntioxidantElectrocorticographyEpilepsyGABAOxidative stress

Identifiers

PMID41236682

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.