Evidence map›Paper›PMID 41236670›Full record

ReviewCurrent heart failure reports2025

Predictors of Left Ventricular Reverse Remodeling in Heart Failure with Reduced Ejection Fraction.

Jeong Hwan Kim, Michael S Kiernan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current heart failure reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jeong Hwan KimDivision of Cardiology, Cardiovascular Center, Tufts Medical Center, Boston, MA, USA.
Michael S KiernanDivision of Cardiology, Cardiovascular Center, Tufts Medical Center, Boston, MA, USA. Michael.Kiernan3@tuftsmedicine.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewWhile left ventricular (LV) remodeling has been associated with poor prognosis in heart failure with reduced ejection, a variable degree of LV remodeling can be reversed upon the removal of the initial insult and with appropriate therapies. Hence, better prediction of LV reverse remodeling would not only help prognostically, but also could illuminate potential therapeutic targets. Herein, we provide a comprehensive review on the latest evidence on the predictors of LV reverse remodeling. RECENT

findingsSeveral predictors of LV reverse remodeling have been identified including certain baseline parameters of underlying cardiomyopathy, myocardial structure and function assessed by multi-modality imaging, and biomarkers. Beyond improving clinical outcomes, many of the established and emerging heart failure therapies have been also demonstrated to promote reverse remodeling, likely reflective of the mechanistic underpinning of their therapeutics benefits. With the ongoing development of novel diagnostics and therapies of heart failure, our understanding of LV reverse remodeling continues to evolve. Furthermore, with the growing evidence between reverse remodeling and clinical outcomes, reverse remodeling may prove to be a clinically useful marker of myocardial recovery and potential therapeutic target.

Indexed as

Heart FailureHeart VentriclesStroke VolumeVentricular Function, LeftVentricular RemodelingBiomarkersHumansPrognosisBiomarkersCardiac remodelingCardiomyopathyHeart failureReverse remodeling

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.